初步探讨利用fMRI技术研究口腔内冷热刺激的中枢反应

目的:利用功能核磁共振成像技术探讨口腔内不同温度刺激的大脑皮层反应的可行性.方法:选取健康志愿者1名.采用自制水传递装置及采用口腔温度刺激过程(温度刺激信号减静息信号)的组块设计方法,fMRI扫描数据用SPM99软件包进行结果的数据分析.结果:本实验温、冷、热刺激左侧口腔黏膜,获得大脑激活区有显著不同,在23℃水刺激口腔时,双侧额上回BA8和额中回BA6、右侧中央前回BA6、顶叶BA40和颞上回BA38可见激活.4℃水刺激时,右侧脑干、岛叶、额上回BA5、额下回BA47、颞下回BA19,左舌回BA18可见激活.56℃水刺激时,双侧额下回BA45、中央前回和岛叶、右舌回、左颞上回可见激活.结论:冷热水刺激激活了不同大脑皮层不同区域,fMRI技术可用于探讨口腔温度感觉的中枢反应的研究.

Pilot Study on Functional Activity Mapping during Intraoral Thermal Sensory Stimulation Using fMRI.

Objective:To primarily evaluate the feasibility of functional magnetic resonance imaging on the location of brain regions related to intraoral thermal stimuli with water.Methods:A volunteer was selected to perform the fMRI study.A self-made water injection device was employed to induce intraoral thermosensory,and block designed BOLD functional magnetic resonance imaging fMRI scan covering the whole brain was carried out.The fMRI data were analyzed by SPM99 software to generate the activation map.Results:The warm,hot and cold stimulations on healthy subject were found to have different activation sites of cerebral cortex.Conclusion:fMRI may be used in exploring human cortical activation induced by intraoral thermal stimuli with water if proper stimulation methods were practiced.The exact brain regions for thermal stimuli need to be made clear by further study.