| 正交试验优选复方儿茶止泻膜的成膜材料 |
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| 引用本文： | 梁波,赵君,高明. 正交试验优选复方儿茶止泻膜的成膜材料[J]. 中国药房, 2011, 0(19): 1764-1766 |
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| 作者姓名： | 梁波 赵君 高明 |
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| 作者单位： | 大连大学医学院; |
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| 基金项目： | 大连市科技计划项目(2008E11SF171) |
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| 摘 要： | 目的:优选复方儿茶止泻膜的成膜材料。方法:以膜剂的外观质量和体外透皮实验中儿茶素的累积释放量为评价指标,以聚乙烯醇(PVA)1750、羧甲基纤维素钠(CMC-Na)、白及胶用量为考察因素,采用正交试验优选最佳成膜材料。结果:最佳成膜材料为PVA17509mL、CMC-Na2mL、白及胶4mL。结论:改进后的复方儿茶止泻膜较单用白及胶作为成膜材料的原制剂,外观质量更好,体外透皮吸收含量更高,能够显著改善原制剂的不足之处。
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| 关 键 词： | 复方儿茶止泻膜 成膜材料 外观质量 体外透皮实验 |
Optimization of Film Materials of Compound Catechu Anti-diarrhea Film by Orthogonal Test |
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| LIANG Bo,ZHAO Jun,GAO Ming. Optimization of Film Materials of Compound Catechu Anti-diarrhea Film by Orthogonal Test[J]. China Pharmacy, 2011, 0(19): 1764-1766 |
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| Authors: | LIANG Bo ZHAO Jun GAO Ming |
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| Affiliation: | LIANG Bo,ZHAO Jun,GAO Ming(Medical College,Dalian University,Dalian 116622,China) |
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| Abstract: | OBJECTIVE:To optimize the film materials of Compound catechu anti-diarrhea film. METHODS:The proportions of film material were optimized by orthogonal experiments using appearance qualtiy and the cumulative drug release of catechin in transdermal tests in vitro as index and with amount of PVA 1750,CMC-Na,bletilla gum as factors. RESULTS:The optimal proportion of film material was as follows:PVA1750 9 mL,CMC-Na 2 mL and bletilla gum 4 mL. CONCLUSION:The improved Compound catechu anti-diarrhea film has the be... |
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| Keywords: | Compound catechu anti-diarrhea film Film materials Appearance quality Transdermal tests |
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