| 甲磺酸帕珠沙星搽剂体外抑菌情况及其对微痤疮模型兔耳的抑制作用研究 |
| |
| 引用本文： | 杨芳,卢登华,尹亚非,路永红,叶永琴. 甲磺酸帕珠沙星搽剂体外抑菌情况及其对微痤疮模型兔耳的抑制作用研究[J]. 中国药房, 2011, 0(21): 1932-1934 |
| |
| 作者姓名： | 杨芳 卢登华 尹亚非 路永红 叶永琴 |
| |
| 作者单位： | 成都市第二人民医院; |
| |
| 基金项目： | 四川省卫生厅科研课题项目(060159) |
| |
| 摘 要： | 目的:考察甲磺酸帕珠沙星搽剂(PL)对痤疮丙酸杆菌的体外抑制情况以及对兔耳微痤疮模型的影响。方法:微量稀释法测定PL对痤疮丙酸杆菌标准菌株及临床分离菌株的最小抑菌浓度(MIC);另用涂抹油酸及皮下注射痤疮丙酸杆菌建立微痤疮模型兔耳,造模后第14天随机分为模型对照组、溶媒对照组、阳性对照组(痤康王0.1mL·kg-1)和PL高、低剂量组(0.3、0.1mL·kg-1),每组6只,右外耳道涂擦相应药物,连续14d,末次给药后18h处死,考察各组兔耳组织学变化及病理评分,并设立空白对照组。结果:PL对受试菌株的MIC均为1.0mg·L-1;与模型对照组比较,阳性对照组和PL高、低剂量组兔耳肉眼可见局部毛囊角栓减少,丘疹变平、减少,表皮增厚脱落不明显;组织学观察可见真皮炎症细胞明显减少,毛囊口扩张减轻;病理评分明显降低(P<0.01)。结论:PL对痤疮丙酸杆菌有明显体外抑制作用,同时对微痤疮模型兔耳有治疗作用。
|
| 关 键 词： | 甲磺酸帕珠沙星搽剂 痤疮丙酸杆菌 最小抑菌浓度 兔耳 抑制作用 |
Antibacterial Effect of Pazufloxacin Mesilate Liniment in Vitro and Its Inhibition Effect on Rabbit Ear Acne |
| |
| YANG Fang,LU Deng-hua,YIN Ya-fei,LU Yong-hong,YE Yong-qin. Antibacterial Effect of Pazufloxacin Mesilate Liniment in Vitro and Its Inhibition Effect on Rabbit Ear Acne[J]. China Pharmacy, 2011, 0(21): 1932-1934 |
| |
| Authors: | YANG Fang LU Deng-hua YIN Ya-fei LU Yong-hong YE Yong-qin |
| |
| Affiliation: | YANG Fang,LU Deng-hua,YIN Ya-fei,LU Yong-hong,YE Yong-qin(Chengdu Municipal Second People's Hospital,Chengdu 610017,China) |
| |
| Abstract: | OBJECTIVE:To investigate the inhibition effect of Pazufloxacin mesilate liniment(PL) on Propionibacterium acnes(P. acnes) in vitro and rabbit ear acne model. METHODS:MIC of PL against P. acnes standard strains and clinical isolated strains were determined by microdilution method. Rabbit ear acne model was established by spreading oleic acid and injecting with P. acnes subcutaneously. 14 days after modeling,the rabbits were randomly divided into model control group,solvent control group,positive control grou... |
| |
| Keywords: | Pazufloxacin mesilate liniment Propionibacterium acnes MIC Rabbit ear Inhibition effect |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
