| 金银花替硝唑含漱液的制备及其质量控制 |
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| 引用本文： | 周燕萍,白海燕,谭杭剑. 金银花替硝唑含漱液的制备及其质量控制[J]. 中国药房, 2011, 0(25): 2360-2362 |
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| 作者姓名： | 周燕萍 白海燕 谭杭剑 |
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| 作者单位： | 武警重庆总队医院药剂科; |
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| 摘 要： | 目的:制备金银花替硝唑含漱液并建立其质量控制方法。方法:以替硝唑、金银花和氯化钠为主药制备含漱液;采用紫外分光光度法(318nm波长)和沉淀吸附滴定法分别测定替硝唑和氯化钠的含量,薄层色谱法鉴别金银花中的绿原酸;考察制剂放置6个月的稳定性。结果:替硝唑检测浓度线性范围为6.08～18.24μg·mL-(1r=0.9998);替硝唑和氯化钠的平均回收率分别为99.81%和99.47%,RSD分别为0.87%和0.70%;制剂放置6个月各指标无明显变化。结论:本制剂制备方法简便易行,质量稳定、可控。
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| 关 键 词： | 金银花替硝唑含漱液 氯化钠 制备 质量控制 紫外分光光度法 |
Preparation and Quality Control of Lonicera japonica and Tinidazole Gargle |
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| ZHOU Yan-ping,BAI Hai-yan,TAN Hang-jian. Preparation and Quality Control of Lonicera japonica and Tinidazole Gargle[J]. China Pharmacy, 2011, 0(25): 2360-2362 |
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| Authors: | ZHOU Yan-ping BAI Hai-yan TAN Hang-jian |
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| Affiliation: | ZHOU Yan-ping,BAI Hai-yan,TAN Hang-jian(Dept.of Pharmacy,Chongqing Armed Police General Hospital,Chongqing 400061,China) |
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| Abstract: | OBJECTIVE: To prepare Lonicera japonica (L.japonica) and tinidazole gargle,and to establish quality control method.METHODS: Tinidazole,L.japonica and sodium chloride were used as the main components to prepare gargle.UV spectrophotometry (318 nm wavelength) and precipitation absorption titration were used to determine the concentration of tinidazole and sodium chloride.TLC was used to identify chlorogenic acid in L.japonica.The stability of preparation within 6 months was investigated.RESULTS: The linear ra... |
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| Keywords: | Lonicera japonica and tinidazole gargle Sodium chloride Preparation Quality control UV spectrophotometry |
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