| 尼莫地平与阿米三嗪萝巴新治疗老年糖尿病合并脑功能异常的临床观察 |
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| 引用本文： | 杨炳川,方应权. 尼莫地平与阿米三嗪萝巴新治疗老年糖尿病合并脑功能异常的临床观察[J]. 中国药房, 2011, 0(20): 1885-1888 |
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| 作者姓名： | 杨炳川 方应权 |
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| 作者单位： | 重庆三峡医药高等专科学校第二附属医院; |
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| 摘 要： | 目的:观察尼莫地平与阿米三嗪萝巴新治疗老年糖尿病合并脑功能异常的疗效和安全性。方法:将60例糖尿病合并不同程度脑功能异常患者随机分为治疗组和对照组,各30例。2组均为住院治疗患者,均给予一般治疗,治疗组在一般治疗的基础上用阿米三嗪萝巴新片每次1片,bid,分别于早、晚餐时服用;对照组在一般治疗的基础上口服尼莫地平30mg,tid。疗程均为4周。疗程结束后观察2组治疗前、后症状的变化及不良反应。结果:治疗后治疗组总有效率为83.31%,对照组为60.0%,2组比较差异有统计学意义(P<0.05)。治疗后治疗组红细胞各项指标均较治疗前有所下降,且差异有统计学意义(P<0.001),而对照组改变不明显(P>0.05),2组间比较差异有统计学意义(P<0.001);治疗组在治疗后动脉血氧分压(PaO2)较治疗前明显升高(P<0.01),动脉血二氧化碳分压(PaCO2)较治疗前明显下降,差异有统计学意义(P<0.01);但对照组治疗后PaO2和PaCO2与治疗前比较,差异无统计学意义(P>0.05);2组治疗后心脏功能状态较治疗前差异无统计学意义(P>0.05)。2组均未发现明显不良反应。结论:阿米三嗪萝巴新片对老年糖尿病合并脑功能异常具有明显疗效,在改善心肺功能方面,阿米三嗪萝巴新明显优于尼莫地平,且使用安全,值得进一步研究。
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| 关 键 词： | 老年 脑功能障碍 阿米三嗪萝巴新片 尼莫地平 心功能 肺功能 糖尿病 |
Clinical Observation of Duxil and Nimodipine in the Treatment of Aged Diabetes Complicating with Cerebral Dysfunction |
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| YANG Bing-chuan,FANG Ying-quan. Clinical Observation of Duxil and Nimodipine in the Treatment of Aged Diabetes Complicating with Cerebral Dysfunction[J]. China Pharmacy, 2011, 0(20): 1885-1888 |
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| Authors: | YANG Bing-chuan FANG Ying-quan |
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| Affiliation: | YANG Bing-chuan,FANG Ying-quan(The Second Affiliated Hospital of Chongqing Three Gorges Medical College,Chongqing 404000,China) |
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| Abstract: | OBJECTIVE: To observe the therapeutic efficacy of duxil and nimodipine in the treatment of aged diabetes complicating with cerebral dysfunction. METHODS: 60 patients suffering from aged diabetes complicating with cerebral dysfunction were randomly divided into treatment group and control group with each group of 30 cases, which both were treated with general therapy. Besides, treatment group was treated with duxil one tablet twice a day at breakfast and supper while control group was treated with Nimodipine... |
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| Keywords: | Aged Cerebral dysfunction Duxil Nimodipine Heart function Lung function Diabetes |
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