甲钴胺联合前列地尔治疗糖尿病周围神经病变的疗效观察

目的:观察甲钴胺联合前列地尔治疗糖尿病周围神经病变的疗效。方法:将96例糖尿病周围神经病变患者随机均分为2组。所有患者均给予糖尿病饮食、运动治疗及胰岛素强化治疗,血糖稳定后,2组均肌肉注射甲钴胺500μg·d-1,qd,观察组同时静脉滴注前列地尔100μg·d-1,qd,2组疗程均为30d。疗程结束后评定疗效。结果:观察组的有效率为97.92%,对照组的有效率为79.17%,2组比较差异有统计学意义(P<0.01)。2组治疗后的感觉神经传导速度较治疗前比较,差异有统计学意义(P<0.01),且观察组感觉神经传导速度变化较对照组显著(P<0.01)。结论:甲钴胺联合前列地尔治疗糖尿病周围神经病变可有效改善患者的症状,提高临床疗效,且不良反应轻微。

Efficacy Observation of Mecobalamin Alprostadil Treatment of Diabetic Peripheral Neuropathy

OBJECTIVE： To observe the methylcobalamin with alprostadil treatment of diabetic peripheral neuropathy. METHODS： The patients were given the 48 cases of diabetes diet, exercise, therapy and intensive insulin therapy, blood sugar stable, the observation group intramuscular injection of methylcobalamin 500 μg·d-1, qd, while intravenous infusion of alprostadil 100 μg·d-1, qd, continuous treatment of 30 d. The control group mecobalamin 500 μg·d-1, qd, treatment with the observation group. A course of treatment evaluated. RESULTS： The group’s effective rate was 97.92%, effective rate of the control group 79.17%, a significant difference between the 2 groups （P0.01）. After treatment, the sensory nerve conduction velocity than before treatment （P0.01）, the difference was significant, and the observed changes in sensory nerve conduction velocity group than in the control group was significantly （P0.01）. CONCLUSION： Methylcobalamin with alprostadil treatment of diabetic peripheral neuropathy Diabetic peripheral neuropathy can improve symptoms, improve clinical efficacy.