还原型谷胱甘肽辅助治疗小儿急性肾小球肾炎的疗效观察

目的:观察还原型谷胱甘肽辅助治疗小儿急性肾小球肾炎的疗效。方法:将常规处理的急性肾小球肾炎患儿随机分为治疗组(27例)和对照组(26例)。治疗组在对照组基础上加用还原型谷胱甘肽12mg·kg-1·d-1辅助治疗。结果:与对照组比较,治疗组水肿消退时间、尿量和血压恢复正常时间显著缩短(P<0.05)。治疗2周后,治疗组血清尿素氮、24h尿蛋白定量和尿红细胞排泄率均较对照组显著降低(P<0.05)。2组均未见明显不良反应发生。结论:还原型谷胱甘肽有助于小儿急性肾小球肾炎的恢复,且不良反应少。

Efficacy Observation of Adjunctive Therapy of Reduced Glutathione for Pediatric Acute Glomerulonephritis

OBJECTIVE： To observe the therapeutic efficacy of adjunctive therapy of reduced glutathione for pediatric acute glomerulonephritis. METHODS： Children with acute glomerulonephritis receiving conventional treatment were randomly divided into treatment group （27 cases）and control group （26 cases）. The control group with convertional therapy, treatment group were additionally given adjunctive therapy of reduced glutathione 12 mg·kg-1·d-1. Both of 2 groups were treated for 2 weeks. RESULTS： Compared with control group,the recovery time of oedema,urinary production and blood pressure of treatment group were decreased significantly （P0.05）. After 2 week-treatment,the serum urea nitrogen,24 h urine protein quantitation and excretory rate of urine erythrocyte in treatment group were lower than in control group significantly（P0.05）. There wasn’n ADR appeared in 2 groups. CONCLUSION： Reduced glutathione is benefit for the recovery of pediatric acute glomerulonephritis.