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AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines |
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| Authors: | Lee-Jun C Wong Pu Dai Jyh-Feng Lu Mary Ann Lou Robert Clarke Viktor Nazarov |
| Institution: | (1) Department of Molecular and Human Genetics, Baylor College of Medicine, 77030 Houston, Texas, USA;(2) Department of Otolaryngology, Head Neck Surgery, Chinese PLA General Hospital, 100853 Beijing, China;(3) Fu Jen Catholic University, School of Medicine, Taipei, Taiwan;(4) Department of Surgery, Cardinal Tien Hospital, Hsintien Taipei Hsien, Taiwan;(5) Department of Oncology, Georgetown University Medical Center, 20007 Washington, DC, USA |
| Abstract: | BackgroundThe poly Q polymorphism in AIB1 (amplified in breast cancer) gene is usually assessed by fragment length analysis which does not reveal the actual sequence variation. The purpose of this study is to investigate the sequence variation of poly Q encoding region in breast cancer cell lines at single molecule level, and to determine if the sequence variation is related to AIB1 gene amplification. |
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