西酞普兰配合治疗难治性精神分裂症效果研究

目的探讨西酞普兰对难治性精神分裂症的辅助治疗作用。方法将60例难治性精神分裂症的患者随机等分为两组,其中治疗组以氯氮平合并西酞普兰治疗,对照组单独用氯氮平治疗,共治疗2个疗程,于治疗前及治疗第6、12周后对患者的阳性与阴性症状量表PANSS和简明精神量表BPRS进行评定。结果治疗第6周起治疗组PANSS总分及BPRS总分均比治疗前有所降低,且优于对照组（P〈0.05）。两组患者均无不良反应病例发生。结论配合使用西酞普兰对改善难治性精神分裂症症状能起到更好的效果。

Study of adjuvant effect of citalopram in treatment of refractory schizophrenia

Objective To investigate the adjuvant effect of citalopram in the treatment of refractory schizophrenia.Methods Sixty patients with refractory schizophrenia were randomly divided into two groups,of which the treatment group received clozapine combined with citalopram treatment and the control group received single clozapine for 2 treatment courses.Before the treatment and at the 6th and 12th weeks of the treatment,the positive and negative syn drome scale（PANSS） and the brief psychiatric rating scale（BPRS） were used to evaluate the patient ’s positive and negative symptoms.Results From the 6th week of treatment,the total scores of PANSS and BPRS of the treatment group reduced compared to before the treatment,which were superior to the control group（P〈0.05）.No adverse reaction was observed in either group.Conclusion The adjuvant application of citalopram is conducive to improving the symptoms of refractory schizophrenia.