不同剂量万托林雾化吸入对急性支气管哮喘患儿心率及疗效的影响

目的观察万托林雾化吸入治疗急性哮喘患儿的疗效与安全性。方法将74例年龄在7～12岁间的急性支气管哮喘患儿分为四组。治疗剂量A组雾化吸入0.3 mL 0.5%万托林;B组采用0.4 mL 0.5%万托林;C组采用0.5 mL 0.5%万托林;对照组吸入硫酸特布他林气雾剂。观察各组症状、体征消失时间、疗效及对心率影响等不良反应。结果 A、B、C组治疗后总有效率分别为73.7%、88.9%、94.4%,B、C组与对照组的总有效率相比,差异有统计学意义（P〈0.05）。C组不良反应有所增加,A、B组未出现明显副作用。结论依据不同剂量万托林总有效率及不良反应情况,B组为急性哮喘患儿的最佳治疗剂量。

The effect of ventolin inhalation therapy on the heart rate and efficacy in treatment of acute bronchial asthma in children

Objective To observe the efficacy and safety of ventolin aerosol inhalation therapy in children with acute asthma.Methods Seventy-four cases children aged between 7-12 years with acute bronchial asthma were divided into four groups.Therapeutic dose of group A was 0.3 mL of 0.5% ventolin atomization inhalation,and doses of group B and group C were 0.4 and 0.5 mL of 0.5% ventolin,respectively.Control group inhaled sulfuric acid terbutaline aerosol.Observed the symptoms,signs disappeared,and its effect on heart rate and adverse reaction of each group.Results The total effective rates of group A,B,C were 73.7%,88.9% and 94.4%,respectively.Conpared with control group,group B and C had significant different（P〈0.05）.The side effect of group C increased,but that of group B and C was not obvious.Conclusion According to the side-effect and total efficiency of each group,we knew that group B was the best clinical dosage of ventolin for acute bronchial asthma in children.