| 哺乳动物促性腺激素抑制激素的生殖内分泌调节与行为作用 |
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| 引用本文： | 孟凡森,陈学群,杜继曾. 哺乳动物促性腺激素抑制激素的生殖内分泌调节与行为作用[J]. 浙江大学学报(医学版), 2013, 42(2): 224-231. DOI: 10.3785/j.issn.1008-9292.2013.02.015 |
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| 作者姓名： | 孟凡森 陈学群 杜继曾 |
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| 作者单位： | 浙江大学医学院基础医学系，浙江 杭州 310058 |
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| 基金项目： | 国家重点基础研究发展计划资助项目 |
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| 摘 要： | 哺乳动物中促性腺激素抑制激素（gonadotropin-inhibitory hormone，GnIH）同源物（RF-amide related peptide，RFRP）的神经元胞体主要存在于下丘脑背内侧核（dorsomedial hypothalamic nucleus，DMH），其神经纤维主要投射到视前区（preoptic area，POA）和下丘脑正中隆起，其受体主要分布在下丘脑。RFRP神经元投射到促性腺激素释放激素（gonadotropin-releasing hormone，GnRH）神经元上；最终，RFRP和GnRH共同完成哺乳动物生殖轴功能调节。
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| 关 键 词： | 促性腺激素抑制激素 促性腺激素释放激素 生殖 应激 摄食 |
| 收稿时间： | 2012-02-08 |
Gonadotropin-inhibitory hormone in regulation of reproduction and behavior in mammalians |
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| MENG Fansen , CHEN Xuequn , DU Jizeng. Gonadotropin-inhibitory hormone in regulation of reproduction and behavior in mammalians[J]. Journal of Zhejiang University. Medical sciences, 2013, 42(2): 224-231. DOI: 10.3785/j.issn.1008-9292.2013.02.015 |
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| Authors: | MENG Fansen CHEN Xuequn DU Jizeng |
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| Affiliation: | Department of Basic Medical Sciences，Zhejiang University School of Medicine，Hangzhou 310058，China |
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| Abstract: | RF-amide related peptide(RFRP) is the orthologue of gonadtropin-inhibitory hormone(GnIH) in mammals.The bodies of RFRP cell are located in the dorsomedial nucleus of the hypothalamus(DMH) and the fibers project to preoptic area(POA) and median eminence of the hypothalamus.Its receptor mainly distributes in hypothalamus.RFRP fibers project to GnRH cells to regulate mammalian reproduction axis.This paper reviews the progress of current researches on RFRP in regulation of animal behaviors，including reproduction，food intake，anxiety and stress response. |
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| Keywords: | Gonadotropin-inhibitory hormone Gonadotropin-releasing hormone Reproduction Stress Food intake |
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