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复方山泽降脂方降脂作用实验研究
引用本文:刘津,马志刚,李建银,卢志标,陈刚,程亚坤,马媛媛.复方山泽降脂方降脂作用实验研究[J].中南药学,2013,11(4):255-257.
作者姓名:刘津  马志刚  李建银  卢志标  陈刚  程亚坤  马媛媛
作者单位:刘津 (兰州大学药学院,兰州,730000); 马志刚 (兰州大学药学院,兰州,730000); 李建银 (兰州大学药学院,兰州,730000); 卢志标 (兰州大学药学院,兰州,730000); 陈刚 (兰州大学药学院,兰州,730000);程亚坤 (兰州大学药学院,兰州,730000);马媛媛 (兰州大学第一医院药剂科,兰州,730000);
摘    要:目的探讨效验复方山泽降脂方(SZ)对实验性高脂血症大鼠血脂的调节作用。方法用脂肪乳剂灌胃造成大鼠实验性高脂血症动物模型,以复方山泽降脂方3.5、7、14 g.kg-1低、中、高剂量组给予大鼠灌胃28 d后,经腹主动脉取血,测血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)。结果与高脂模型组比较,高剂量SZ能显著降低血清TC、TG、LDL-C水平和动脉硬化指数(AI)(P〈0.01或P〈0.05),但对HDL-C的影响不大。结论复方山泽降脂方对高脂血症大鼠的脂质代谢有一定的调节作用,提示其对高脂血症的防治具有应用价值。

关 键 词:复方山泽降脂方  高脂血症  调血脂作用

Lipid-regulating effect of compound Shanze Jiangzhi decoction
LIU Jin,MA Zhi-gang,LI Jian-yin,LU Zhi-biao,CHEN Gang,CHENG Ya-kun,MA Yuan-yuan.Lipid-regulating effect of compound Shanze Jiangzhi decoction[J].Central South Pharmacy,2013,11(4):255-257.
Authors:LIU Jin  MA Zhi-gang  LI Jian-yin  LU Zhi-biao  CHEN Gang  CHENG Ya-kun  MA Yuan-yuan
Institution:1. School of Pharmacy, Lanzhou University, Lanzhou 730000; 2. Department of Pharmacy, First Hospital of Lanzhou Univer- sity, Lanzhou 730000)
Abstract:Objective To explore the lipid-regulating effect of compound Shanze Jiangzhi decoction (SZ). Methods Hy- perlipidemia rat model was established by gastric perfusion with fat emulsion. SZ was given at 3.5, 7 and 14 g . kg - 1 for 28 d, and the blood samples were collected via aorta abdominalis to measure the serum cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C). Results Compared with the model group, the SZ high dose group remarkably reduced TC, TG, and LDL-C levels in the serum, and decreased athero- genic index value (P 〈 0.01 or P 〈 0.05). Conclusion SZ can adjust the serum lipid, prevent and treat hyperlipidemia.
Keywords:compound Shanze Jiangzhi decoction  hyperlipidemia  lipid-regulating effect
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