ER、PR、P53及CerbB2蛋白在乳腺导管原位癌中的表达及意义

目的探讨乳腺导管原位癌不同组织学分级中ER、PR、P53及CerbB2蛋白表达情况。方法收集80例乳腺导管原位癌标本,参照Van Nuys分类方法,对80例乳腺导管原位癌按核的分级、有无坏死进行组织学分级,并对所有标本行ER、PR、P53及CerbB2蛋白的免疫组化染色。结果低级别ER、PR、P53及CerbB2的阳性率分别为90.00%、85.00%、55.00%、25.00%;中级别ER、PR、P53及CerbB2的阳性率分别为88.50%、80.80%、46.20%、50.00%;高级别ER、PR、P53及CerbB2的阳性率分别为35.30%、29.40%、67.60%、82.40%。统计学分析ER、PR及CerbB2蛋白在低级别与高级别组,中级别与高级别组中表达差异有统计学意义（P〈0.01）。结论ER、PR和CerbB2蛋白在乳腺癌的发展过程中起着重要作用,可以作为判断肿瘤分级较好的指标。

Expression of ER,PR,P53,CerbB2 in ductal carcinoma in situ of the breast and its significance

Objective To study the expression of ER,PR,P53 and CerbB2 in ductal carcinoma in situ（DCIS） of the breast and explore their relationship with the pathological grade.Methods A total of 80 samples of DCIS were collected.According to Van Nuys classification,all the samples were divided into three groups.The ER,PR,P53 and CerbB2 expression was examined by immunohistochemistry.Results The positive rates of ER,PR,P53 and CerbB2 were 90.00%,85.00%,55.00% and 25.00% respectively in the low grade group;The positive rates of ER,PR,P53 and CerbB2 were 88.50%,80.80%,46.20% and 50.00% respectively in the median grade group;The positive rates of ER,PR,P53 and CerbB2 were 35.30%,29.40%,67.60% and 82.40% respectively in the high grade group.The ex pression of ER and PR in the low and median grade group was significantly higher than that in the high grade group.Conversely,the expression of CerbB2 in the low and median grade group was significantly lower than that in the high grade group.Conclusion ER,PR and CerbB2 may play an important part during the development process of breast cancers.They can be served as ideal biomarkers for the classification of pathological grade in breast tumors.