沙美特罗替卡松联合孟鲁司特钠治疗儿童变异性哮喘疗效和安全性分析

目的探讨沙美特罗替卡松联合孟鲁司特钠治疗儿童变异性哮喘（variant asthma,VA）的临床疗效及安全性。方法分析我院自2008年4月～2012年4月收治的变异性哮喘患儿124例,按随机数字表法分为治疗组64例、对照组60例。治疗组给予沙美特罗替卡松和孟鲁司特钠。对照组单用沙美特罗替卡松。两组均以6个月为一个疗程。观察两组肺功能变化、临床总体疗效及安全性问题。结果 （1）治疗前两组肺功能达标率（25.0%、23.3%）,两组比较差异无统计学意义（P〉0.05）。治疗后3个月（67.2%、41.4%）、6个月（79.7%、57.1%）、12个月（87.5%、65.0%）,两组肺功能达标率比较差异有统计学意义（P〈0.05）。（2）治疗组与对照组总有效率分别为95.3%（61/64）、80.0%（48/60）,两组比较差异有统计学意义（χ2=6.828,P〈0.01）。（3）治疗组与对照组复发率分别为4.7%、18.6%,两组比较差异有统计学意义（P〈0.05）。结论沙美特罗替卡松联合孟鲁司特钠治疗儿童变异性哮喘可以增加患者肺功能,提高临床有效率,减少疾病的复发,值得临床推广。

Efficacy and safety of salmeterol fluticasone plus montelukast sodium in the treatment of variant asthma in children

Objective To explore the clinical curative effect and safety of salmeterol fluticasone plus montelukast sodi um in the treatment of variant asthma（VA） in children.Methods A total of 124 cases of variant asthma were analyzed from April 2008 to April 2012.They were divided into treatment group（64 cases）,which used salmeterol fluticasone plus mon telukast sodium,and control group（60 cases）,which used tsalmeterol fluticasone.There were 6 months for one course in both groups.Lung function changes,the overall clinical curative effect and safety issues in both groups were ob served.Results（1） The standard rate of lung function of two groups before treatment were 25.0% and 23.3%.There was no statistically significant（P〈0.05）.The standard rate were 67.2% and 41.4% after treatment 3 month,79.7% and 57.1% after 6 month,87.5% and 65.0% after 12 month.There was statistically significant between two groups（P〈0.05）.（2） The total effective rate between control group and treatment group were 95.3%（61/64）,80.0%（48/60）.There was statistically significant differences between two groups（χ2=6.828,P 0.01）.（3） The relapse rate between control group and treatment group were 4.7%,18.6%.There was statistically significant between two groups（P〈0.05）.Conclusion The application of salmeterol fluticasone plus montelukast sodium in the treatment of variant asthma in chil dren can increase the pulmonary function in patients,improve clinical efficiency,and reduce the recurrence of the dis ease.It’s worthy of clinical application.