SLE患者过氧化氢酶基因-330位点单核苷酸多态性研究

目的 探讨过氧化氢酶(CAT)-330位点单核苷酸多态性与系统性红斑狼疮(SLE)的相关性。方法 用聚合酶链反应（PCR）-限制性片段长度多态性法对CAT基因-330多态性位点作基因分型。结果 患者组和正常对照组间CAT-330CC、-330CT及-330TT基因型频率均无统计学差异，但活动期SLE患者中CAT-330CC基因型频率显著高于静止期SLE患者和正常人对照组，且CAT-330CC基因型与SLE患者肾损害、血液学改变以及抗U1RNP抗体和抗dsDNA抗体产生有关。结论 CAT-330CC基因型与SLE的一些临床特征相关联，拥有CAT-330CC基因型的患者病情严重，预后差。

Catalase gene-330 single nucleotide polymorphism in patients with systemic lupus erythematosus

Relationship between catalase –330 single nucleotide polymorphisms and systemic lupus erythematosus. Peng Xuebiao，Li Fuli. Department of Dermatology,Nanfang Hospital,Nanfang Medical University,Guangzhou,510515,china. Abstract] Objective To investigate the relationship between catalase –330 single nucleotide polymorphisms and systemic lupus erythematosus. Method CAT -330 polymorphisms was analyzed by polymerse chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results We did not observe significant difference in the prevalence of CAT-330C/T polymorphic variants(CC,CT,TT) in SLE patients and normal controls. However,we found that the CAT-330CC gene frequency was significantly increased in active SLE,compared to in inactive ones and normal controls. We also observed that CAT-330 CC genetype showed a significant association with renal manifestation,blood system changes and presence of anti-dsDNA antibody and anti-U1RNP antibody in the patients with SLE. Conclusion Our findings suggest that CAT-330 genetype may contribute to some clinic manifestations in SLE patients,those patients who have CAT-330CC genetype will suffer from more severe illness and poor prognosis.