| 微波及离子液体条件下香豆素类化合物的合成研究 |
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| 引用本文： | 朱占洲,豆甲泰,许维恒,季大伟,王小燕,何邦平,孙青龑. 微波及离子液体条件下香豆素类化合物的合成研究[J]. 药学实践杂志, 2009, 27(6): 448-450 |
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| 作者姓名： | 朱占洲 豆甲泰 许维恒 季大伟 王小燕 何邦平 孙青龑 |
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| 作者单位： | 1. 第二军医大学研究生管理大队学员14队,上海,200433
2. 第二军医大学药学院,上海,200433 |
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| 基金项目： | 第二军医大学教学研究重点项目，第二军医大学大学生创新重点项目 |
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| 摘 要： | 目的：探索操作简便、环境友好的香豆素衍生物的合成方法：方法：以乙酰乙酸乙酯和苯酚类化合物为原料，通过Pechmann反应，在4种不同的反应条件（浓硫酸催化、Lewis酸三氯化铋催化、微波Lewis酸三氯化铋催化、微波离子液体催化）下催化合成多种香豆素衍生物，并对4种方法进行对比。结果：微波离子液体条件下的Pechmann反应与传统方法相比革除了有机溶剂的使用，缩短了反应时间且产率较高。结论：微波及离子液体条件下合成香豆素类化合物是一种条件简单、环境友好的合成方法。
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| 关 键 词： | 香豆素类化合物 微波加热 离子液体 Pechmann反应 |
| 收稿时间： | 2009-05-05 |
Synthesis of coumarins by Pechmann reaction under microwave irradiation and green solvent ionic liquid |
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| ZHU Zhan-zhou,DOU Jia-tai,XU Wei-heng,JI Da-wei,WANG Xiao-yan,HE Bang-ping and SUN Qing-yan. Synthesis of coumarins by Pechmann reaction under microwave irradiation and green solvent ionic liquid[J]. The Journal of Pharmaceutical Practice, 2009, 27(6): 448-450 |
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| Authors: | ZHU Zhan-zhou DOU Jia-tai XU Wei-heng JI Da-wei WANG Xiao-yan HE Bang-ping SUN Qing-yan |
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| Affiliation: | 14th Team, Graduate Management Unit, Second Military Medical University, Shanghai 200433, China;14th Team, Graduate Management Unit, Second Military Medical University, Shanghai 200433, China;14th Team, Graduate Management Unit, Second Military Medical University, Shanghai 200433, China;14th Team, Graduate Management Unit, Second Military Medical University, Shanghai 200433, China;College of Pharmacy, Second Military Medical University, Shanghai 200433, China;College of Pharmacy, Second Military Medical University, Shanghai 200433, China;College of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Objective:To explore an easily-controled,environmentally-benign synthetic method of coumarin derivatives.Methods:Several coumarin derivatives are synthesized from phenols and ethyl acetoacetates by the Pechmann reaction under four different conditions(H2SO4,BiCl3,Microwave/BiCl3,Microwave/ionic liquid).Results:Compared with traditional reaction,present method under microwave and ionic liquid avoids using of organic solvent,shorten the reaction period and obtain a good yield.Conclusion:Microwave accelerated Pechmann reaction using ionic liquid as catalyst is a convenient and green alternative for synthesizing coumarin derivatives. |
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| Keywords: | coumarin derivatives microwave irradiation ionic liquid Pechmann reaction |
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