非小细胞肺癌组织中p53和雌激素受体的表达及其临床意义与相关性

目的探讨非小细胞肺癌（NSCLC）中p53蛋白和雌激素受体（ER）表达与临床病理的相关性。方法应用免疫组织化学S-P法检测63例NSCLC癌组织标本及20例良性病变中p53、ER的表达。结果p53总阳性率为52.3%（33/63）,其中鳞癌阳性率为55.2%（21/38）,腺癌阳性率48.0%（12/25）,而20例良性病变中均未检测到p53阳性表达。ER总阳性率为74.6%（47/63）,其中鳞癌阳性率65.8%（25/38）,腺癌阳性率88.0%（22/25）,在20例良性病变中均无ER表达。p53、ER的阳性表达与性别、年龄、组织学类型及病理分级无明显相关。结论p53和ER在NSCLC中的表达可视为两个独立的因素并以各自独立的方式参与肺癌的发生发展。在ER表达阳性的病例中,临床上辅以内分泌治疗可奏效。

Clinical Significance and Expression of p53 Protein and Estrogen Receptors in Non Small Cell Lung Cancer

Objective To investigate the relationships between expression of tumor suppressor gene P53 ,estrogen receptor （ER） and clinic pathology in human non small lung cancer （NSCLC）. Methods The expression of P53 protein and ER in 63 NSCLC specimen and 20 specimen from patients with benign lung disease were detected by SP immunonhistochemistry method. Results 52.3% tumor tissues had positive P53 staining, and the positive rate in squamous cell carcinoma and adenocarcinoma was 55.2% and 48.0%, respectively ;74.6% tumor tissues had positive expression of ER, and the positive rate in squamous cell carcinoma and adenocarcinoma was 65.8% and 88.0% ,respectively. There was no expression of p53 and ER in benign pulmonary lesion tissues. The positive rates of p53 and ER expression were not associated with gender, age, histology type and pathological steps, conclusion The expressions of P53 and ER in NSCLC can be considered to be two independent factors involved in the occurrence and development of lung cancer.