外源性硫化氢对急性氧中毒的影响

目的研究外源性硫化氢对急性氧中毒的影响。方法昆明小鼠随机分为3组(n=12):正常对照组、生理盐水组+高压氧暴露组、硫氢化钠(NaHS)组+高压氧暴露组。动物暴露前按分组腹腔注射生理盐水和NaHS(50μmol/kg)溶液后立即进舱暴露(100%纯氧,压力500 kPa,40 min),观察动物惊厥潜伏期,出舱后检测脑组织丙二醛(MDA)和一氧化氮(NO)含量。结果外源性硫化氢可减轻急性氧中毒的损伤,延长惊厥潜伏期,降低脑组织MDA和NO含量。结论外源性硫化氢对急性氧中毒造成的脑损伤具有保护作用,其机制可能与降低NO含量有关。

Effect of exogenous H2S on acute oxygen toxicity

Abstract] Dendrimer is a newly synthesized nano-material with natural nanometer-size, unique monodispersion, and multifunctional surface groups.And all these unique properties have led to its wide use in biomedical domain, especially in targeted drug delivery.The drug molecules can be either encapsulated in the hydrophobic chambers inside the dendritic skeleton,or chemically conjugated to the functional groups on the surface of dendrimer. The multifunctional surface groups can be linked chemically to various target ligands, including monoantibody and its Fab fragment, folic acid, biotin, etc, which lead to the delivery of drugs to the targeted sites for targeted therapy. This article mainly discusses the application of dendrimers in targeted drug delivery and introduces the toxic property of dendrimer.