Exercise and the Prevention of Oesophageal Cancer (EPOC) study protocol: a randomized controlled trial of exercise versus stretching in males with Barrett's oesophagus |
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| Authors: | Brooke M Winzer Jennifer D Paratz Marina M Reeves David C Whiteman |
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| Affiliation: | (1) The University of Queensland, School of Medicine, Burns, Trauma & Critical Care Research Centre, Brisbane, QLD 4029, Australia;(2) Cancer Prevention Research Centre, School of Population Health, The University of Queensland, Brisbane, QLD 4006, Australia;(3) Cancer Control Group, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia |
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| Abstract: | Background Chronic gastro-oesophageal reflux disease and excessive body fat are considered principal causes of Barrett's oesophagus (a metaplastic change in the cells lining the oesophagus) and its neoplastic progression, oesophageal adenocarcinoma. Metabolic disturbances including altered levels of obesity-related cytokines, chronic inflammation and insulin resistance have also been associated with oesophageal cancer development, especially in males. Physical activity may have the potential to abrogate metabolic disturbances in males with Barrett's oesophagus and elicit beneficial reductions in body fat and gastro-oesophageal reflux symptoms. Thus, exercise may be an effective intervention in reducing oesophageal adenocarcinoma risk. However, to date this hypothesis remains untested. |
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