Latest and Emerging Therapies for Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis |
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Authors: | Claudia O Zein Keith D Lindor |
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Institution: | (1) Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, 200 First Street, SW, Rochester, MN 55905, USA; |
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Abstract: | Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are the two most common causes of chronic cholestatic
liver disease in adults. In PBC, therapy with ursodeoxycholic acid (UDCA) is safe and has been associated with tangible biochemical,
histologic, and survival benefits. However, a need for different or adjuvant therapies remains for specific subsets of PBC
patients, including those who do not respond to UDCA and those who have advanced histologic disease at presentation. Similarly,
beneficial therapies for disease-related symptoms that do not typically respond to UDCA (eg, fatigue and pruritus) are still
needed. In contrast to PBC, no medical therapy of proven benefit has been identified for patients with PSC. In PBC and PSC,
adequate management of complications of chronic cholestasis is important. For both diseases, liver transplantation is the
only curative option. |
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Keywords: | |
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