抗内毒素抗体治疗严重烧伤内毒素血症29例

目的 研究抗内毒素抗体与抗生素对严重烧伤并发症——内毒素血症的治疗作用。方法29例患者随机分为拮抗内毒素治疗组和常规治疗组。并在烧伤后不同时相点测定了血浆内毒素、血清TNF、血浆IL-6和血浆IL-8的含量。结果抗生素和抗内毒素抗体治疗可明显减少患者血中内毒素水平（P〈0.05），同时降低IL-6，IL-8和TNF血中含量，而单用抗生素治疗对降低血中内毒素水平作用不明显。结论选择合适的抗生素配合抗内毒素抗体的早期应用，是治疗烧伤后内毒素血症及其并发症的有效方法。

Anti-LPS antibody and antibiotic treatment in burns

Objective To study the therapeutic effect of anti-LPS antibody and different antibiotic in treatment and prevention of sepsis a common complication of serious burns.Methods Twenty-nine patients were divied into anti-LPS+antibiotic treatment group and antibiotic treatment group.Plasma endotoxin,serum TNF,IL-6 and IL-8 were detected at different time phase after burn.Results The results showed that the antibodies to LPS could decrease the level of LPS,IL-6,IL-8 and TNF obviously,but some antibiotic couldn't decrease the level of LPS,IL-6,IL-8 and TNF obviously in blood.Impenem was a weak endotoxin inducer and ceftazidime and ciprofloxacin were stronger endotoxin inducers.Conclusion The appropriate selection of antibiotics and anti-LPS antibody has a considerable influence on treating sepsis and its complications after serious burns.