男男性接触者梅毒感染危险因素病例-对照研究

目的探讨与男男性接触者（MSM）梅毒感染有关的危险因素。方法采用应答驱动抽样（RDS）、关键知情人介绍、网上招募、同志酒吧招募等方法在安徽省合肥、芜湖、淮南3个城市招募研究对象，共有261名符合条件的男男性接触者（MSM）接受了梅毒和人类免疫缺陷病毒（HIV）抗体血清学检测。采用病例对照研究方法，将梅毒初筛和确认试验均阳性者22例作为病例组。按年龄上下相差1岁以内、职业相近的条件进行1：4配比．从梅毒检测阴性者中选取了88人作为对照，对研究对象进行面对面问卷调查。结果单因素分析结果显示．MSM人群HIV／性传播疾病（STDS）感染危险性意识低．同性性伴总数≥10个，近6个月同性性伴数≥3个，经常参加同性恋组织聚会、有同性肛交偶然性伴以及肛交偶然性伴以及肛交安全套使用率低于75％与梅毒感染有关。多因素条件Logistic回归分析显示，HIV／STDS感染危险意识低，近6个月同性肛交偶然性伴数多、肛交安全套使用率低是梅毒感染的主要危险因素。结论在MSM人群进行性病的干预，重点为提高该人群HIV／STIs感染危险性意识，减少性伴数和提高安全套使用率。

Case- control study on risk factors of syphilis infection among homosexual men

Objective To explore related risk factors of syphilitic infection among men having sex with men(MSM).Methods Two hundred and sixty-one eligible homosexual men were recruited to participate in the study by using Driven Sampling(RDS)and informative key person's referral and internet advertising and direct contacts in gay bars in Hefei and Wuhu and Huainan.Of participants,twenty-two MSM were infected with syphilis.Case-control study based on result of test of syphilis was conducted.Ration of cases to controls was 1:4 depending on age and occupation.The participants were interviewed by face to face.Variables included social demographic characteristics,number of homosexual and heterosexual partners,sexual behaviours and venues of social activities and result of HIV-test.Results Lower awareness of HIV/STIs infection,multiple sexual partners,frequently participating in homosexual party,having casual sex partner,lower rate of condom use when having anal intercourse were risk factors of syphilis infection.Conclusion The risk behavioral intervention should be emphasized for increasing awareness of HIV/STIs infection and reducing number of sexual partners and promoting condom use.