| 糖尿病患者胰岛素基因启动子的突变检测和临床应用 |
| |
| 引用本文： | 段滨红,刘国信,詹晓蓉,阴慧清,刘晓民. 糖尿病患者胰岛素基因启动子的突变检测和临床应用[J]. 黑龙江医学, 2000, 0(2): 1-2 |
| |
| 作者姓名： | 段滨红 刘国信 詹晓蓉 阴慧清 刘晓民 |
| |
| 作者单位： | 1. 黑龙江省医院
2. 哈尔滨医科大学第一附属医院内分泌科 |
| |
| 基金项目： | 黑龙江省自然科学基金，， |
| |
| 摘 要： | 目的 :探讨胰岛素基因启动子突变是否与中国人 2型糖尿病相关。方法 :随机选择黑龙江省中国汉族人 89例 2型糖尿病 ,应用聚合酶链式反应———单链象多态性 (PCR -SS CP)检测方法检测胰岛素启动子突变。结果 :89例 2型糖尿病中未发现 1例异常泳动变化。结论 :胰岛素基因启动子突变可能不是中国人 2型糖尿病的重要遗传因素。文献报道美国黑人中胰岛素基因启动子突变 ( 8个碱基TGGTCTAA的重复序列 )与 2型糖尿病相关 ,本研究结果提示此种相关有明显的种族异质性
|
| 关 键 词： | 2型糖尿病 胰岛素基因启动子 突变 PCR-SSCP |
| 修稿时间： | 1999-12-05 |
Detection and Clinical Application of Mutatuion of Insulim Gene Promotor in Diabetes |
| |
| The Provincial Hospital of Heilongjiang Duan Binhong Liu Guoxin Zhan Xiaorong et al. Detection and Clinical Application of Mutatuion of Insulim Gene Promotor in Diabetes[J]. Heilongjiang Medical Journal, 2000, 0(2): 1-2 |
| |
| Authors: | The Provincial Hospital of Heilongjiang Duan Binhong Liu Guoxin Zhan Xiaorong et al |
| |
| Affiliation: | The Provincial Hospital of Heilongjiang Duan Binhong Liu Guoxin Zhan Xiaorong et al |
| |
| Abstract: | Objective:To discuss whether there is correlation between the mutation of insulin gene promator and Chinese Ⅱ diabetes.Methods:89 cases diabetesof Han nationality in Heilongjiang province were selected randomly to detect the mutation of insulin gene promotor with (PCR-SSCP) method.Results:There was no abnormal change in 89 cases during dctection.Conclusion:The mutation of insulin gene promotor may not be an important heredity factor in Chinese Ⅱ diabetes.This results suggest that this correlation in American black Ⅱ diabetes according to data. |
| |
| Keywords: | Type Ⅱ diabetes Multation of insulin gene promotor PCR-SSCP |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
