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Protective Effect of Curcumin on Endotoxin-induced Acute Lung Injury in Rats
引用本文:连庆泉,李兴旺,尚游,姚尚龙,马利,金胜威. Protective Effect of Curcumin on Endotoxin-induced Acute Lung Injury in Rats[J]. 华中科技大学学报(医学英德文版), 2006, 26(6): 678-681. DOI: 10.1007/s11596-006-0613-5
作者姓名:连庆泉  李兴旺  尚游  姚尚龙  马利  金胜威
作者单位:Department of Anesthesiology Union Hospital Tongji Medical College Huazhong University of Science and Technology,Department of Anesthesiology the Second Affiliated Hospital and Yuying Children's Hospital Wenzhou Medical College,Department of Anesthesiology Union Hospital Tongji Medical College Huazhong University of Science and Technology,Department of Anesthesiology Union Hospital Tongji Medical College Huazhong University of Science and Technology,Department of Anesthesiology Union Hospital Tongji Medical College Huazhong University of Science and Technology,Department of Anesthesiology the Second Affiliated Hospital and Yuying Children's Hospital Wenzhou Medical College,Wuhan 430022 China,Wenzhou 325027 China,Wuhan 430022 China,Wuhan 430022 China,Wuhan 430022 China,Wenzhou 325027 China
摘    要:Acute lung injury (ALI) or its more severe form, the acute respiratory distress syndrome (ARDS), is a common, devastating clinical syndrome that affects both medical and surgical patients. The most common cause of ALI is sepsis. There is now well-documented evidence that pulmonary inflammation contributes to the devel-opment of ALI. Despite significant advances in our un-derstanding of pathophysiology and technologies in the supportive management, mortality from ALI remains excessive. C…

关 键 词:保护作用 内毒素 急性肺损伤 病理
收稿时间:2006-10-20
修稿时间:2006-10-20

Protective effect of curcumin on endotoxin-induced acute lung injury in rats
Qingquan Lian M.D., Ph.D.,Xingwang Li,You Shang,Shanglong Yao,Li Ma,Shengwei Jin. Protective effect of curcumin on endotoxin-induced acute lung injury in rats[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2006, 26(6): 678-681. DOI: 10.1007/s11596-006-0613-5
Authors:Qingquan Lian M.D.   Ph.D.  Xingwang Li  You Shang  Shanglong Yao  Li Ma  Shengwei Jin
Affiliation:1. Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China
2. Department of Anesthesiology, the Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical College,Wenzhou 325027, China
Abstract:To investigate the protective effect of curcumin on endotoxin-induced acute lung injury in rats, and explore the underlying mechanisms, 24 male Wistar rats were randomly divided into 4 ex-perimental groups: sham-vehicle (S), sham-curcumin (C), lipopolysaccharide (LPS)-vehicle (L), and curcumin-lipopolysaccharide (C-L) groups. The wet/dry (W/D) weight ratio of the lung and bron-choalveolar lavage (BAL) fluid protein content were used as measures of lung injury. Neutrophil re-cruitment and activation were evaluated by BAL fluid cellularity and myeloperoxidase (MPO) activ-ity in cell-free BAL and lung tissue. The levels of cytokine-induced neutrophil chemoattractant-1 (CINC-1) in lung tissues were measured by ELISA. The histopathological changes of lung tissues were observed by using the HE staining. Our results showed that lung injury parameters, including the wet/dry weight ratio and protein content in BALF, were significantly higher in the L group than in the S group (P<0.01). In the L group, higher numbers of neutrophils and greater MPO activity in cell-free BAL and lung homogenates were observed when compared with the S group (P<0.01). There was a marked increase in CINC-1 levels in lung tissues in response to LPS challenge (P<0.01, L group vs S group). Curcumin pretreatment significantly attenuated LPS-induced changes in these indices. LPS caused extensive morphological lung damage, which was also lessened after curcumin pretreatment. All the above-mentioned parameters in the C group were not significantly different from those of the S group. It is concluded that curcumin pretreatment attenuates LPS-induced lung injury in rats. This beneficial effect of curcumin may involves, in part, inhibition of neutrophilic re-cruitment and activity, possibly through inhibition of lung CINC-1 expression.
Keywords:acute lung injury  lipopolysaccharide  neutrophils  CINC-1
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