| 硒对乙醇致大鼠机体损伤的保护作用 |
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| 引用本文： | 石同幸,聂木海,诸茂盛,麦惠霞. 硒对乙醇致大鼠机体损伤的保护作用[J]. 现代预防医学, 2002, 29(2): 186-187 |
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| 作者姓名： | 石同幸 聂木海 诸茂盛 麦惠霞 |
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| 作者单位： | 广州市疾病预防控制中心毒理科,广州,510080 |
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| 摘 要： | 目的 :探讨硒对乙醇致体内脂质过氧化的保护作用及机理。方法 :用 3g/kg体重的乙醇给大鼠灌胃 ,同时自由饮用含硒量为 0 .2 5 mg/L 的亚硒酸钠水溶液 ,饲养三个月。结果 :与单给乙醇组比较 ,乙醇 +Se组大鼠组织和血清 MDA含量显著降低 (P均 <0 .0 1) ,GSH- Px、SOD、CAT活性均升高 (P均 <0 .0 5 )。结论 :硒可能通过增加 GSH- Px、SOD、CAT活性从而抑制过量乙醇对机体的损伤
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| 关 键 词： | 硒 乙醇 脂质过氧化 饮酒 |
| 文章编号： | 1003-8507(2002)02-0186-02 |
| 修稿时间： | 2001-05-29 |
STUDY ON EFFECTS OF SELENIUM ON ALCOHOLIC BODY INJURY OF RAT |
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| SHI Tong-xing,NIE Mu-hai,ZHU Mao-sheng,et al.. STUDY ON EFFECTS OF SELENIUM ON ALCOHOLIC BODY INJURY OF RAT[J]. Modern Preventive Medicine, 2002, 29(2): 186-187 |
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| Authors: | SHI Tong-xing NIE Mu-hai ZHU Mao-sheng et al. |
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| Affiliation: | SHI Tong-xing,NIE Mu-hai,ZHU Mao-sheng,et al.Centre for Disease Preventive and Control of Guangzhou City,Guangzhou 510080,China. |
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| Abstract: | Objective:To study the mechanism that selenium inhibited lipid peroxidation by alcohol causing in vivo.Method:To repeat ingestion alcohol in SD rats at the dose of 3g/kg weight,and fed with the dose of 0.25mg/L selenium(Se) at the same time in three months.Results:The contents of malondiadehyde(MDA) was decreased(P<0.01) and the activities of glutathione peroxidase(GSH-Px),superoxide dismitase(SOD),catalase(CAT) were increased in tissue and serum between alcohol+Se and alcohol groups(P<0.05).Conclusion:The selenium could inhibit the injury of over-dose alcohol to body by elevating activities of GSH-Px,SOD and CAT. |
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| Keywords: | Selenium Alcohol Lipid peroxidation |
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