| 冰片注射液对小鼠实验性脑缺血的保护作用 |
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| 引用本文： | 何晓静,菅凌燕,刘玉兰.冰片注射液对小鼠实验性脑缺血的保护作用[J].新乡医学院学报,2006,23(1):23-25. |
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| 作者姓名： | 何晓静 菅凌燕 刘玉兰 |
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| 作者单位： | 1. 中国医科大学附属第二医院药剂科,辽宁,沈阳,110004
2. 沈阳药科大学药学院,辽宁,沈阳,110016 |
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| 摘 要： | 目的研究冰片注射液对小鼠实验性脑缺血(cerebralischemia)的保护作用及可能作用机制。方法分别采用小鼠断头喘气、负重游泳、负重爬杆及脑缺血再灌注模型,测定小鼠断头后存活时间、爬杆及负重游泳时间及脑缺血再灌注后脑组织匀浆内LDH、Na+-K+-ATP酶、Mg2+-ATP酶、Ca2+-ATP酶的活力。结果冰片注射液能明显提高小鼠断头后的存活时间(P<0.01)、延长爬杆及负重游泳时间(P<0.01)、延长爬杆及负重游泳时(P<0.05),升高缺血再灌注损伤小鼠脑内LDH、Na+-K+-ATP、Mg2+-ATP、Ca2+-ATP酶的活力(P<0.01或P<0.05)。结论冰片具有保护脑缺血的作用,机制可能与其改善缺血脑组织的能量代谢有关。
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| 关 键 词： | 冰片 脑缺血 小鼠 |
| 文章编号： | 1004-7239（2006）01-0023-03 |
| 收稿时间： | 2005-01-17 |
| 修稿时间： | 2005-01-17 |
Protective effects of borneol on experimental cerebral ischemia in mice |
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| HE Xiao-jing,JIAN Ling-yan,LIU Yu-lan.Protective effects of borneol on experimental cerebral ischemia in mice[J].Journal of Xinxiang Medical College,2006,23(1):23-25. |
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| Authors: | HE Xiao-jing JIAN Ling-yan LIU Yu-lan |
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| Institution: | 1. The Second Affiliated Hospital of China Medical University, Shenyang 110004, China ;2. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | Objective To investigate the protective effects of borneol on cerebral ischemia and its mechanism.Methods Three animal were used as models by cutting the heads of mice, crawling bar and swimming with 2 g weights and cerebral ischemia-reperfusion in mice.Results Borneol could significantly prolong gasping time of mice(P<0.01), time of crawling bar and swimming of mice with 2 g weights (P<0.05) and increase activities of LDH, Na~+-K~+-ATP ase、Mg~ 2+ -ATP ase and Ca~ 2+ -ATP ase(P<0.01 or P<0.05).Conclusion Borneol can have protective effects on cerebral ischemia, its mechanisms may be related to the improvement of the metabolism of energy of ischemic brain region. |
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| Keywords: | borneol cerebral ischemia mice |
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