Adrenal medullary responses to insulin-induced hypoglycaemia in the young rat. Influence of thyroid hormones |
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| Authors: | D Gripois M Valens A Diarra |
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| Institution: | 1. Sackler Program for Epigenetics and Developmental Psychobiology at McGill University, Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, Quebec H4H 1R3, Canada;2. Department of Psychiatry, McGill University, Montreal, Quebec H3A 1A1, Canada;1. Toxicity Assessment Division, Neurotoxicology Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA;2. National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA;1. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Oulu and Helsinki, Finland;2. Research Unit for Pediatrics, Pediatric Neurology, Pediatric Surgery, Child Psychiatry, Dermatology, Clinical Genetics, Obstetrics and Gynecology, Otorhinolaryngology and Ophthalmology (PEDEGO), Medical Research Center Oulu, University of Oulu, Oulu, Finland;3. Institute of Health Sciences, Helsinki University Hospital and University of Helsinki, Helsinki, Finland;4. Department of Pediatrics and Adolescence, Oulu University Hospital, Oulu, Finland;5. Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland;6. Department of Children and Families, Oulu and Helsinki, Finland;7. Biocenter Oulu, Oulu, Finland;8. Unit of Primary Care Unit, Oulu, Finland;9. Department of Epidemiology and Biostatistics, Imperial College London, Medical Research Council Health Protection Agency Center for Environment and Health, School of Public Health, London, United Kingdom;10. Department of General Practice and Primary Health Care, Helsinki, Finland;11. Folkhälsan Research Center, Helsinki, Finland;12. Hospital of Children and Adolescents, Helsinki University Hospital and University of Helsinki, Helsinki, Finland;13. Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway;1. University Hospital and Faculty of Medicine, University of São Paulo, São Paulo, Brazil;2. School of Psychology & Discipline of Psychiatry, University of Sydney, Sydney, Australia;3. Department of Biology, Universidad Autónoma de Madrid, Spain;4. Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;5. Collegiate of Biological Sciences, Federal University of Vale do São Francisco, Petrolina, Pernambuco, Brazil;6. Departament of Physiological Sciences, Federal University of Espírito Santo, Vitória, Brasil, Brazil;7. Hospital das Clínicas and Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil;8. Department of Psychology, The Ohio State University, 1835 Neil Avenue, Columbus, OH, 43210, USA;1. CHU Sainte-Justine Research Centre, Montreal, Canada;2. Department of Psychiatry, University of Montreal, Montreal, Canada;3. Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada;4. Department of Psychology, Concordia University, Montreal, Canada;5. Douglas Mental Health University Institute, Verdun, Canada;6. Department of Psychiatry, McGill University, Montreal, Canada;7. School of Psychoeducation, University of Montreal, Montreal, Canada;8. Department of Psychology and Pediatrics, University of Montreal, Montreal, Canada;9. School of Public Health, Physiotherapy and Sports Science, University College Dublin, Ireland |
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| Abstract: | The adrenal medulla of normal, hypothyroid and hyperthyroid young rats was stimulated by insulin-induced hypoglycaemia. In normal rats, insulin-induced adrenal epinephrine secretion increases during the first 10 days of post-natal life. Hypothyroidism retards the development of adrenal response; hyperthyroidism facilitates the development of this response. At 14 days, when insulin-induced adrenal epinephrine depletion is the same for all groups, the recovery of adrenal catecholamines stores after depletion is linear and takes less than 48 h. Recovery rate is slightly slower for hyperthyroid rats than for either hypothyroid or control rats at 14 days. Following epinephrine depletion, adrenal tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) activities are increased for a few days in the control rats, corresponding to a transsynaptic induction. Hypothyroidism impairs TH induction and completely suppresses DBH induction; hyperthyroidism impairs TH induction, but has no effect on DBH induction. These data show that the various processes related to CA synthesis, in the adrenal medulla of the developing rat, are controlled in different ways by the thyroid hormones. |
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