各期高血压患者血液流变学改变及其相关因素的研究

本文采用系统的血液流变学研究方法,观察了245例各期高血压患者的血液流变学改变,同时观察其甲皱微循环和血脂的变化,并与116例正常人作对照。结果表明:高血压患者存在着显著的血液高粘滞状态,表现为全血粘度、血浆粘度和全血还原粘度均明显升高(P<0.001)。这种改变在高血压Ⅰ期即已存在,随着病情发展而加重。同时伴有HCT、EER及红细胞变形能力的明显异常(P<0.01)各期高血压患者均出现明显的甲皱微循环障碍,主要表现为毛细血管袢的严重畸型及其内血流速度缓慢。本结果证实了高血压病理过程中存在着血液流变学异常及微循环障碍。这种改变与病情发展有关。提示其对高血压病理过程的影响。

Study of hemorrheological changes and related factors in patients with hypertension of defferent stages

The standard methods of hemorrheologv were used to study the changes of hemorrhe- ological parameters as well as nailfold microcirculation in 245 patients with hypertension of different stages and 116 healthy persons as control. The results ind- icated that the patients had siginficant hypervisity and plasma viscosity (P<0.001). This kind of hyperviscosity, accompanied with increased EER(P<0.01), appeared at hypertension of the first stage and became worse as the disease developed. The impedement in naifold microcirculation were also observed in every stage of hypertension. The work thus confirmed the presence of the abnormalities of he- morrheology and microcirculation in hypertension and pointed the possible effects of these. abnormalities in the development of the disease.