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| 大豆皂甙和人参茎叶皂甙的抗糖尿病动脉粥样硬化作用 | |
| 作者单位： | Department of Patholgy，Basic Medical College |
| 摘 要： | 本实验分别经胃给糖尿病（ＤＭ）大鼠大豆皂甙（ＳＳ）１０ｍｇ／（ｋｇ·ｄ）和人参茎叶皂甙（ＧＳ）１５０ｍｇ／（ｋｇ·ｄ）共２０周。观察ＳＳ和ＧＳ对主动脉的形态学作用及血糖、血清胰岛素、血脂、脂质过氧化物、超氧化物歧化酶、血小板聚集率和ＴｘＡ２／ＰＧＩ２的作用。结果表明ＳＳ和ＧＳ通过降低血糖、脂质过氧化物，血小板聚集率，ＴｘＡ／ＰＧＩ２和提高胰岛素水平及提高超氧化物歧化酶含量，对实验性ＤＭ动脉粥样硬化的发生和发展起有效的防治作用。本文还对其作用机理进行了初步探讨。 |
| 关 键 词： | 动脉硬化／药物疗法，糖尿病／药物疗法，大豆皂甙，人参皂甙／药理学，过氧化脂质类／代谢 |
Antiatherosclerotic effect of soyasaponin and ginsen-stem-leaves saponin in diabetes |
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| Authors: | Wang Yinping Wu Jiaxiang Wang Xinrui Zhang Fenglan |
| Abstract: | The investigation was taken to diabetic rats given soyasapnin(SS)10 mg/(kg·d)and ginsen-stem-leaves saponin(GS)150 mg/kg/day for 20 weeks,respectively。The ef-fect of SS and GS on aorta,and blood glucose,serum insulin,lipids,platelet aggregation ratesand TXA2/PGI2 were observed。The results suggested that SS and GS played an efficacious pre-ventive and treatment role in control of the development of experiment diabetes and its atheroscle-rosis by decreasing blood glucose,LPO,platelet aggregation rate,and TXA/PGI,and increas-ing SOD and insulin levels。The mechanism was also discussed preliminarily. |
| Keywords: | atheros/erosis/drug ther diabetes/drug ther soyasaponin panaxosides/ pharm lipid peroxides/metab |
| 本文献已被 CNKI 等数据库收录！ | |