Adaptive response of microglial cells to in vitro infection by Candida albicans isolates with different genomic backgrounds |
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Authors: | Neglia Rachele Colombari Bruna Peppoloni Samuele Orsi Carlotta Tavanti Arianna Senesi Sonia Blasi Elisabetta |
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Institution: | Dipartimento di Scienze di Sanità Pubblica, Università di Modena e Reggio Emilia, 41100 Modena, Italy. |
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Abstract: | It has been recently demonstrated that Candida albicans isolates with distinct genomic backgrounds (namely, b and c genotypes) express different susceptibility to antifungal activity by human monocytes in vitro. We show here that, although comparable in their ability to undergo dimorphic transition and in susceptibility to phagocytosis by microglial cells, the b and c isolates show striking differences in terms of intracellular survival. Only the c genotype resists indeed to intracellular killing and eventually replicates inside microglial cells, that in turn respond to fungal infection, preferentially towards the c genotype, with nuclear factor-kappaB (NF-kappaB) activation and increased Mip1alpha production. These data indicate that C. albicans-microglial cell interaction is strictly dependent upon fungal genotype, strengthening the potential significance of genotyping as prognostic parameter in clinical infections by C. albicans. |
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Keywords: | Candida albicans Genotype Macrophages Microglial cells Virulence Phagocytosis Killing |
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