| 环磷酰胺对小鼠Peyer‘s结和肠道粘膜相关淋巴细胞的影响 |
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| 引用本文： | 周华,王培训,刘良,周联. 环磷酰胺对小鼠Peyer‘s结和肠道粘膜相关淋巴细胞的影响[J]. 中国免疫学杂志, 2001, 17(4): 186-187,189,F002 |
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| 作者姓名： | 周华 王培训 刘良 周联 |
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| 作者单位： | 1. 广州中医药大学,
2. 香港浸会大学, |
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| 基金项目： | 国家“九五”攀登计划预选项目(98008) |
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| 摘 要： | 目的：研究环磷酰胺对Peyer‘s结和肠道粘膜相关淋巴细胞的影响。建立肠道粘膜免疫障碍模型。方法：剂量为100mg/kg的环磷酰胺，观察不同时间处理后小鼠Peyer‘s结数目在24h时降低最明显，结内细胞数量和CD3^ 、IgA^ 细胞也明显减少，而细胞凋亡明显增加。结论：环磷酰胺可诱导肠粘膜免疫障碍，这可能是其引起淋巴细胞的细胞凋亡而产生的。
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| 关 键 词： | 环磷酰胺 肠道粘膜 淋巴细胞 影响 Peyer‘s结 抗癌药 免疫障碍 |
| 文章编号： | 1000-484X(2001)04-0186-03 |
The influnence ofcyclophosphamide on Peyper's patches and intestinal mucosal as-sociated lymphocytes inmice |
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| Abstract: | Objective:To understand the influence of cyclophosphamide to Peyer's patches and intestinal mucosal associated lymphocytes and establish an intestinal mucosal immune dysfunction model Methods:Investigate the number of Peyer's patches of mice at different time points and the total cell number of Peyer's patches, the number of CD3 and IgA cell, apoptosis at 24 h after being treated with 100 mg/kg cyclophosphamide Results:Cyclophosphamide could induce markedly decreasing of Peyer's patches at 24 h after treatment, at which the total cell number of Peyer's patches, the number of CD3 and IgA cell decreased significantly, and the apoptosis increased obviously Conclusion:Cyclophosphamide can induce the dysfunction of intestinal mucosal immune in mice, which is maybe mediated by the apoptosis of lymphocytes |
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| Keywords: | Cyclophosphamide Intestine mucosa immune Influence |
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