| 三氧化二砷（As2O3）治疗多发性骨髓瘤机理的研究进展 |
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| 引用本文： | 周秀杰,周郁鸿.三氧化二砷（As2O3）治疗多发性骨髓瘤机理的研究进展[J].河南中医药学刊,2010(6):1052-1054. |
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| 作者姓名： | 周秀杰 周郁鸿 |
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| 作者单位： | [1]浙江中医药大学,浙江杭州310053 [2]浙江中医药大学第一附属医院,浙江杭州310053 |
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| 基金项目： | 浙江省自然科学基金（编号：Y2101416） |
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| 摘 要： | 目的：分析三氧化二砷治疗多发性骨髓瘤的作用机理。方法：综合分析有关三氧化二砷治疗多发性骨髓瘤的文献。结果与结论：三氧化二砷治疗多发性骨髓瘤的机理主要包括：抑制多发性骨髓细胞的增殖，并促进其凋亡；改变多发性骨髓性细胞基因表达并抑制其新生血管；影响其基质细胞增殖和分泌。
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| 关 键 词： | 三氧化二砷 多发性骨髓瘤 骨髓基质细胞 基因表达 血管新生 |
Research Progress Of Arsenic Trioxide In Treating Multiple Myeloma |
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| ZhouXiujie,ZhouYuhong.Research Progress Of Arsenic Trioxide In Treating Multiple Myeloma[J].Journal of Henan college of Traditional Chinese Medicine,2010(6):1052-1054. |
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| Authors: | ZhouXiujie ZhouYuhong |
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| Institution: | 1.zhejiang university of chinese medicine, Hangzhou, Zhejiang, China 310053;2.The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang, China 310053) |
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| Abstract: | Objective： To analyse the mechanism of arsenic trioxide treatment of multiple myeloma. Methods： A comprehensive analysis of the literature about arsenic trioxide on the treatment of multiple myeloma. Results and conclusion： The arsenic trioxide treatment of multiple myeloma mechanism was as follows： multiple bone marrow cell proliferation, and promote its apoptosis, change the multiple myeloma cells gene expression and its new blood vessels, Affect the secretion of cell proliferation and matrix. |
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| Keywords: | arsenic trioxide multiple myeloma bone marrow stromal cells gene expression angiogenesis |
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