| 褪黑素对大鼠心肌缺血再灌注损伤的保护作用 |
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| 引用本文： | 明章银,吴基良,李立中,蒋建刚.褪黑素对大鼠心肌缺血再灌注损伤的保护作用[J].咸宁医学院学报,2000,14(3):166-168. |
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| 作者姓名： | 明章银 吴基良 李立中 蒋建刚 |
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| 作者单位： | 咸宁医学院临床药学系药理学教研室,咸宁 |
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| 摘 要： | 目的：探讨褪黑素对大鼠心肌缺血再灌注损伤的影响。方法：采用大鼠在体心肌缺血再灌注模型，观察褪黑素对再灌注心律失常的影响。测定其血清ＬＤＨ、ＣＫ、ＳＯＤ、ＭＤＡ的含量。结果：褪黑素降低再灌注心律失常的发生率，降低室颤发生率，缩短心律失常持续时间，升高血清ＳＯＤ活性，降低血清ＭＤＡ、ＬＤＨ、ＣＫ含量。结论：褪黑素对大鼠心肌缺血再灌注损伤有保护作用。
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| 关 键 词： | 褪黑素 大鼠 心肌缺血 再灌注损伤 心肌保护 |
| 修稿时间： | 2000-06-20 |
Effect of Melatonin on Myocardial Ischemia /Reperfusion Injury in Rats |
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| MING Zhangyin,WU JiLing,LI Lizhong et al.Effect of Melatonin on Myocardial Ischemia /Reperfusion Injury in Rats[J].Journal of Xianning Medical College,2000,14(3):166-168. |
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| Authors: | MING Zhangyin WU JiLing LI Lizhong |
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| Institution: | MING Zhangyin,WU JiLing,LI Lizhong et al Department of Pharmacology,Xianing Medical College,Xianning 437100 |
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| Abstract: | Objective To study the effect of melatonin on myocardial ischemia/reperfusion injury in rats.Methods The left coronary anterior decending branch was ligated and then reperfused.The incidence of arrhythmia and its duration,and the contents of serum LDH,CK,SOD and MDA,were measured.Results Compared with the control,melatonin reduced the incidence of arrhythmia and ventricular fibrillation,shortened the duration of arrhythmia and decreased the content of lactate dehydrogenase and creatine kinase.Conclusion Melatonin has a protective effect on the injury induced by myocardial ischemia/reperfusion. |
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| Keywords: | Melatonin Myocardial injury of myocardium Arrhythmia |
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