| 葡萄糖激酶调节蛋白的研究进展 |
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| 引用本文： | 方亦斌,邹大进. 葡萄糖激酶调节蛋白的研究进展[J]. 华夏医学, 2003, 16(3): 422-423 |
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| 作者姓名： | 方亦斌 邹大进 |
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| 作者单位： | 第二军医大学附属长海医院内分泌科,上海,200433 |
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| 摘 要： | 葡萄糖激酶调节蛋白(glucokinase regulatory protein，GKRP)是一种主要存在于肝细胞内分子量68kDa的蛋白质，能与葡萄糖激酶(glucokinase，GK)结合而抑制其活性。由于葡萄糖激酶在糖代谢中的重要作用：GK基因突变与青年发病型糖尿病(maturity—onset diabetes of theyoung，MODY)发病的关系，尤其是最近发现的GKRP对糖尿病的治疗作用，使GKRP的研究价值得到了进一步的肯定。GKRP基因治疗可能会成为2型糖尿病治疗史上的新突破。
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| 关 键 词： | 葡萄糖激酶 调节蛋白 糖尿病 |
| 文章编号： | 1008-2409(2003)03-0422-02 |
| 修稿时间： | 2002-10-18 |
Research Progress on Glucokinase Regulatory Protein |
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| FANG Yi Bin,ZOU Da jin//. Research Progress on Glucokinase Regulatory Protein[J]. Acta Medicinae Sinica, 2003, 16(3): 422-423 |
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| Authors: | FANG Yi Bin ZOU Da jin// |
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| Affiliation: | FANG Yi Bin,ZOU Da jin//Department of Endocrinology,Changhai Hospital Affiliated to Second Military Medical University,Shanghai 200433,China |
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| Abstract: | Glucokinase regulatory protein(GKRP) is a 68kD protein mainly exists in the heptocyte. Because it can depress the activity of glucokinase(GK) by combinning to it and may play an important role in the maturity onset diabetes of the young (MODY), particularly a recent detection of its function to treat diabetes type II, make the research of GKRP more valuable. GKRP gene therapy may become a breakthrough in treatment of type II diabetes. |
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| Keywords: | glucokinase regulatory protein diabetes mellitus |
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