替格瑞洛联合比伐卢定对STEMI-PCI患者血小板抑制率、聚集率及预后的影响

目的 观察替格瑞洛联合比伐卢定对行冠状动脉介入治疗的ST段抬高心肌梗死(STEMI-PCI)患者血小板抑制率、聚集率及预后的影响.方法 以2014年2月至2015年1月本院心内科收治的80例STEMI-PCI患者为研究对象,随机数字表法均分为观察组和对照组.对照组给予替格瑞洛治疗,观察组替格瑞洛联合比伐卢定治疗,比较治疗后两组血小板抑制率、聚集率及预后.结果 治疗后,观察组血小板抑制率(80.98±9.98)％]较对照组(48.89±8.89)％]显著高(P＜0.05);两组治疗后血小板聚集率均较治疗前显著降低,且观察组血小板聚集率(35.69±5.01)％、(29.21±4.33)％、(24.2l±3.21)％]均较对照组显著降低(P＜ 0.05);观察组治疗后不良事件总发生率显著低于对照组(P＜0.05);两组不良反应发生率差异无统计学意义(P＞0.05).结论 替格瑞洛联合比伐卢定对STEMI-PCI患者改善血小板抑制、聚集作用均显著,对患者预后效果佳.

Effect of ticagrelor combined with bivalirudin on platelet inhibition rate,aggregation rate,and prognosis in patients with STEMI-PCI

Objective To observe the effect of ticagrelor combined with bivalirudin on the platelet inhibition,aggregation rate,and prognosis in patients with ST segment elevation myocardial infarction and undergoing percutaneous coronary intervention (STEMI-PCI).Methods Eighty patients with STEMI-PCI admitted into our hospital from February,2014 to January,2015 were randomized into an observation group and a control group.The control group was treated with ticagrelor and the observation group ticagrelor and bivalirudin.The effects on platelet inhibition rate,aggregation rate,and prognosis were compared between these two groups after treatment.Results After treatment,the platelet inhibition rate was significantly higher in the observation group than in the control group (80.98±9.98)％ vs.(48.89±8.89)％] (P ＜ 0.05).The platelet aggregation rates were significantly lower after than before treatment in both groups.The platelet aggregation rates in the observation group (35.69±5.01)％,(29.21±4.33)％,(24.21±3.21)％] were significantly lower than those in the control group (P ＜ 0.05).The incidence of adverse events after treatment was significantly lower in the observation group than in the control group (P ＜ 0.05).There was no statistical difference in the incidence of adverse reactions between these two groups (P＞0.05).Conclusions Ticagrelor combined with bivalirudin can significantly improve platelet inhibition and aggregation in patients with STEMI-PCI,and the patients' prognosis is good.