雷贝拉唑对成人活动期胃溃疡患者的疗效及溃疡愈合质量的影响

目的 探讨雷贝拉唑在治疗成人活动期胃溃疡上的临床效果以及对溃疡愈合质量的影响.方法 将本院收治的124例成人活动期胃溃疡患者作为研究对象,按照入院治疗的先后将其分为治疗组(63例)和对照组(61例).治疗组采用雷贝拉唑进行治疗;对照组采用奥美拉唑进行治疗.治疗后从镜下溃疡恢复情况、临床症状变化及胃黏膜组织学三个方面对两组患者的治疗效果及溃疡愈合质量进行对比评价.并记录两组患者的不良反应发生情况,观察其用药安全性.结果 从溃疡恢复情况来看,治疗组的总有效率为92.06％,与对照组(83.61％)比较差异有统计学意义(P＜0.05).两组患者在临床上表现为腹痛、灼烧感、腹胀、反酸等症状,治疗结束后,治疗组的各症状积分均显著低于对照组,同时治疗组的各项胃黏膜组织学评分也均优于对照组,差异有统计学意义(P＜0.05).而治疗组的不良反应发生率为7.94％,与对照组(6.56％)比较差异无统计学意义(P＞0.05),临床用药较为安全.结论 雷贝拉唑在治疗成人活动期胃溃疡上的临床效果优于奥美拉唑,同时在缓解临床症状、促进溃疡炎症消退、促使胃黏膜组织快速恢复上效果更佳,能显著提高溃疡愈合质量,值得在临床应用上积极推广.

Clinical efficacy of rabeprazole in adult patients with active gastric ulcer and its effect on the quality of ulcer healing

Objective To investigate the curative effect and the quality of ulcer healing of rabeprazole in the treatment of adult active gastric ulcer.Methods 124 adult patients with active gastric ulcer in our hospital were selected as the research object,and divided into treatment group (63 cases) and control group (61 cases) according to the order of admission.Treatment group was treated with rabeprazole,while control group was treated with omeprazole.After treatment,compared and evaluated the treatment effect and the quality of ulcer healing in two groups in accordance with endoscopic ulcer recovery,clinical symptoms,and gastric mucosal histology.Recorded adverse reactions in two groups,and observed the safety of the drug.Results The total effective rate of treatment group was 92.06％,with statistically significant difference compared with that of control group (83.61％) (P＜0.05).Clinical manifestations of two groups were abdominal pain,heartburn,abdominal distension,acid reflux and other symptoms;after treatment,the symptom scores of treatment group were significantly lower than those of control group,and the scores of gastric mucosal histology of treatment group were better than those of control group,with statistically significant differences (P＜0.05).The incidence of adverse reactions of treatment group was 7.94％,without statistically significant difference compared with that of control group (6.56％) (P＞0.05),the clinical use of drugs was safe.Conclusions The clinical effect of rabeprazole was superior to omeprazole in the treatment of adult active gastric ulcer.At the same time,in relieving clinical symptoms,promoting ulcer inflammation resolution,promoting the rapid recovery of gastric mucosa,the effect is better.Rabeprazole can significantly improve the quality of ulcer healing,it is worth promoting in clinical application.