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阿加曲班预防宫颈癌同步放化疗患者下肢静脉血栓的效果观察
引用本文:林益彬,徐沁. 阿加曲班预防宫颈癌同步放化疗患者下肢静脉血栓的效果观察[J]. 国际医药卫生导报, 2016, 0(19). DOI: 10.3760/cma.j.issn.1007-1245.2016.19.009
作者姓名:林益彬  徐沁
作者单位:福建医科大学教学医院福建省肿瘤医院妇瘤科, 福州,350000
摘    要:目的 比较阿加曲班和低分子肝素用于预防宫颈癌同步放化疗患者下肢静脉血栓的效果.方法 选取60例宫颈癌放化疗的病例,按随机数表分为阿加曲班组和低分子肝素组两组,每组30例.阿加曲班组采用阿加曲班注射液,低分子肝素组采用低分子肝素钙.用药过程中监测患者活化部分凝血活酶时间(APTT),统计血栓形成、出现不良反应的例数,比较两组患者用药前后症状和体征的变化.结果 用药后,阿加曲班组APTT水平第1d为(39.05±7.51)s,第7d为(38.16±8.55)s,第14 d为(38.67±7.52)s,阿加曲班组活化部分凝血活酶时间显著短于低分子肝素组(P<0.05),阿加曲班组血栓形成、出现不良反应各1例,显著低于低分子肝素组的3例和6例(P<0.05).结论 阿加曲班对预防宫颈癌同步放化疗患者下肢静脉血栓的效果优于低分子肝素.

关 键 词:下肢静脉血栓  阿加曲班  低分子肝素  宫颈癌同步放化疗

Effect of argatroban in preventing deep vein thrombosis in patients with cervical cancer underwent concurrent radiotherapy and chemotherapy
Abstract:Objective To compare the effect of argatroban and low molecular weight hepadn (LMWH) in preventing deep vein thrombosis in patients with cervical cancer underwent concurrent radiotherapy and chemotherapy.Methods 60 cases of cervical cancer underwent concurrent radiotherapy and chemotherapy were randomly divided into argatroban group and LMWH group according to the random number table,30 cases in each group.Argatroban group was treated with argatroban injection,while LMWH group was treated with LMWH.Monitored the level of activated partial thromboplastin time (APTT) of patients during medication,recorded the number of cases of thrombosis and adverse reactions,and compared the symptoms and signs of patients before and after medication.Results After medication,the level of APTT of argatroban group on the 1st,7th,14th day were (39.05±7.51)s,(38.16±8.55)s,(38.67±7.52)s,significantly lower than those of LMWH group (P<0.05).There were 1 case of thrombosis and 1 case of adverse reaction in argatroban group,3 cases of thrombosis and 6 cases of adverse reactions in LMWH group (P<0.05).Conclusion The effect of argatroban in preventing deep vein thrombosis in patients with cervical cancer underwent concurrent radiotherapy and chemotherapy is better than that of low molecular weight heparin.
Keywords:Deep vein thrombosis  Argatroban  Low molecular weight heparin  Cervical cancer chemoradiotherapy
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