围绝经期功能失调性子宫出血应用妈富隆和米非司酮治疗的疗效分析

目的 观察妈富隆和米非司酮在围绝经期功能失调性子宫出血患者中的临床疗效,促进精准诊疗.方法 选择2012年6月至2015年12月本院妇科门诊就诊的200例围绝经期功能失调性子宫出血患者作为观察对象,根据治疗方式的不同将其分为观察组和对照组,观察组在诊断性刮宫术后3天给予妈富隆治疗,对照组在诊断性刮宫术后3天给予米非司酮治疗,比较两组患者的治疗效果、止血时间、血清性激素水平、子宫内膜厚度情况.结果 观察组患者治愈78例,有效21例,治愈率为99.00％,对照组患者治愈71例,有效17例,治愈率88.00％,差异有统计学意义(P＜0.05);观察组发生不良反应4例,对照组9例,经比较差异有统计学意义(P＜0.05).观察组患者控制出血时间为(18.44± 4.88)h,对照组控制出血时间为(29.26± 11.18)h,两组比较差异有统计学意义(P＜0.05);观察组完全止血时间为(36.87±11.89)h,对照组完全出血时间为(51.27±18.01)h,两组比较差异有统计学意义(P＜0.05);治疗前,观察组与对照组患者子宫内膜厚度差异无统计学意义(P＞0.05),治疗后,观察组患者子宫内膜厚度较对照组厚,差异有统计学意义(P＜0.05);观察组促卵泡生成素、黄体生成素和雌激素与治疗前相比有所下降,与对照组相比浓度降低,差异有统计学意义(P＜0.05),对照组血清雌激素浓度水平变化差异无统计学意义(P＞0.05).结论 在治疗围绝经期功能性出血患者方面,妈富隆具有较高的临床疗效,且能够抑制血清促卵泡生成素的释放,降低内源性性激素和黄体生成素水平,安全可靠,值得借鉴.

Marvelon and mifepristone in treatment of perimenopausal dysfunctional uterine bleeding

Objective To observe the clinical effect of marvelon and mifepristone for patients with perimenopausal dysfunctional uterine bleeding and improve accurate diagnosis and treatment.Methods 200 patients with perimenopausal dysfunctional uterine bleeding treated at the gynecology clinic of our hospital from June 2012 to December,2015 were selected as observation objects and were divided into a control group and an observation group according to different treatment methods.3 days after curettage,the observation group were treated with marvelon and the control group mifepristone.The treatment effect,hemostasis time,serum sex hormone levels,endometrial thickness were compared between these two groups.Results 78 were cured and 21 effective in the observation group,with a cured rate of 99.00 ％;and 71 cured and 17 effective in the control group,with a cured rate of 88.00 ％;with a statistical difference (P＜0.05).4 cases occurred adverse reactions in the observation group and 9 in the control group,with a statistical difference (P＜0.05).The hemostasis time and completely hemostasis time were (18.44±4.88) h and (36.87±11.89) h in the observation group and were (29.26±11.18) h and (51.27±18.01) h in the control group,with statistical differences(P＜0.05).Before treatment,there was no statistical difference in endometrial thickness before these two groups (P＞ 0.05);after treatment,the endometrial thickness was thicker in the observation group than in the control group,with a statistical difference (P＜0.05).The levels of follicle-stimulating hormone,luteinizing hormone,and estrogen were lower after than before the treatment in the observation group and were in the observation group than in the control group after the treatment,with statistical differences (P＜0.05).The serum level of estrogen after treatment wasn't statistically different from that before treatment in the control group (P＞ 0.05).Conclusions Marvelon in the treatment of perimenopausal dysfunctional uterine bleeding is quite effective,safe,and reliable and can suppress the release of serum FSH and reduce endogenous sex hormones and luteinizing hormone levels,so it is of reference.