甲状腺功能亢进症合并肝功能损害的临床分析

目的 探讨甲状腺功能亢进症(甲亢)合并肝功能损害的临床特点及影响因素.方法 选取2010年1月至2015年6月本院50例甲亢合并肝功能损害患者作为研究组,同期50例甲亢无肝功能损害患者作为对照组,检测两组患者血清甲状腺激素水平及肝功能指标.结果 研究组患者血清总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、游离三碘甲状腺原氨酸(FT3)及游离甲状腺素(FT4)分别为(6.16±1.54) nmol/L、(265.36±24.56) nmol/L、(20.13±3.65) pmol/L、(56.82±7.55) pmol/L,均高于对照组,组间比较差异有统计学意义(t=6.922 6、18.632 3、10.647 2、14.331 1,P＜0.001),两组患者促甲状腺素(TSH)比较差异无统计学意义(t=2.142 9,P＞0.05).研究组患者常见的肝功能异常指标为ALP、TBIL、ALT、AST和γ-GT,所占比例分别为54.0％、10.0％、22.0％、20.0％和12.0％.结论 甲状腺功能亢进症与肝损伤相互影响,甲亢性肝损害与患者甲状腺激素水平密切相关.

Hyperthyroidism complicated with liver dysfunction

Objective To investigate the clinical characteristics and influencing factors of patients with hyperthyroidism complicated with liver dysfunction.Methods 50 patients with hyperthyroidism complicated with liver dysfunction treated at our hospital were set as a study group and 50 patients with hyperthyroidism not complicated with liver dysfunction treated at our hospital during the same period were set as a control group.The serum thyroid hormone levels and the indicators of liver function were tested.Results The serum levels of total three iodine thyroid original ammonia acid (TT3),total thyroxine (TT4),free three iodine thyroid original ammonia acid (FT3),and free thyroxine (FT4) were (6.16± 1.54) nmol / L,(265.36±24.56) nmol / L,(20.13 ±3.65) pmol / L,and (56.82±7.55 pmol / L) in the study group,which were higher than those in the control group,with statistical differences (t=6.922 6,18.632 3,10.647 2,and 14.331 1,P＜0.001).There was no statistical difference in thyroid stimulating hormone (TSH) between these two groups (t=2.1429,P＜0.05).The liver function indicators,ALP,TBIL,ALT,AST,and γ-GT,were abnormal in the study group;the proportions were 54.0％,10.0％,22.0％,20.0％,and 12.0％,respectively.Conclusions Hyperthyroidism interacts with liver damage.Hyperthyroidisminduced liver damage closely correlates with the patients' thyroid hormone levels.