幽门螺旋杆菌根除对幽门螺旋杆菌相关性胃病患者血清COX-2影响

目的 探讨幽门螺旋杆菌(Hp)根除对幽门螺旋杆菌相关性胃病患者血清COX-2影响.方法 将2014年7月至2016年1月本医院收治的310例Hp相关性胃病患者按照病理学诊断结果分为胃溃疡组117例、十二指肠溃疡组96例和慢性萎缩性胃炎组97例,另选择同期在医院体检的健康人群60例作为对照组,所有感染Hp患者均行标准四联疗法,记录胃病患者Hp根除率;分别抽取各组受试对象肘静脉血,采用酶联免疫吸附试验检测四组血清环氧合酶-2(Cyclooxygenase-2,COX-2)水平.结果 310例胃病患者Hp根除273例,总根除成功率88.1％ (273/310);胃溃疡组、十二指肠溃疡组Hp根除成功率比较差异无统计学意义(x 2=2.375,P＞0.05),胃溃疡组、十二指肠溃疡组Hp根除成功率显著高于慢性萎缩性胃炎组(x2=3.996、9.162,P＜0.05).胃溃疡组、十二指肠溃疡组、慢性萎缩性胃炎组血清COX-2显著高于对照组(P＜0.05);胃溃疡组、十二指肠溃疡组血清COX-2又显著高于慢性萎缩性胃炎组(P＜0.05),胃溃疡组、十二指肠溃疡组两组间COX-2水平比较差异无统计学意义(P＞0.05).Hp根除成功的胃溃疡组、十二指肠溃疡组、慢性萎缩性胃炎组患者治疗后血清COX-2显著降低,与治疗前比较差异具有统计学意义(P＜0.05);Hp根除失败的胃溃疡组、十二指肠溃疡组、慢性萎缩性胃炎组患者治疗前后血清COX-2比较差异均无统计学意义(P＞0.05).结论 Hp相关性胃病患者在成功根除Hp后,血清COX-2会显著降低,血清COX-2可以作为Hp根除疗效评价指标之一.

Influence of Helicobacter pylori eradication on serum level of COX-2 in patients with Helicobacter pylori related gastric disease

Objective To explore the influence of Helicobacter pylori eradication on the serum level of COX-2 in patients with Helicobacter pylori related gastric disease.Methods 310 patients with Helicobacter pylori related gastric disease treated at our hospital from July,2014 to January,2016 were divided into a gastric ulcer group (117 cases),a duodenal ulcer group (96 cases),and a chronic atrophic gastritis group (97 cases) according to the pathological diagnosis results.60 healthy people were selected as a control group.All the Hpinfected patients underwent standard quadruple therapy.The Hp eradication rates were recorded.The ulnar vein blood was extracted from all the objects.The serum levels of Cyclooxygenase-2 in the four groups were detected by enzyme-linked immunosorbent assay method.Results Among the 310 gastric disease patients,273 cases' HP were eradicated,with an Hp eradication rate of 88.1％ (273/310).The HP eradication rate in the gastric ulcer group was not statistically different from that in the duodenal ulcer group (x 2=2.375,P＜0.05).The HP eradication rate was significantly higher in the gastric ulcer group and the duodenal ulcer group than in the chronic atrophic gastritis group (x 2=3.996,9.162,P＜0.05).The serum level of COX-2 was significantly higher in the gastric ulcer group,the duodenal ulcer group,and the chronic atrophy gastritis group than in the control group (P＜0.05).The serum level of COX-2 was significantly higher in the gastric ulcer group and the duodenal ulcer group than in the chronic atrophic gastritis group (P＜0.05).The was no statistical difference in the serum level of COX-2 between the gastric ulcer group and the duodenal ulcer group (P＞0.05).The serum level of COX-2 was significantly higher after than before successful HP eradication in the gastric ulcer group,the duodenal ulcer group,and the chronic atrophic gastritis group (P＜0.05).There were no statistical differences in the serum level of COX-2 between before and after failure HP eradication in the gastric ulcer group,the duodenal ulcer group,and the chronic atrophic gastritis group (P＞0.05).Conclusions After the successful eradication of Hp in patients with Hp related gastric disease,the serum level of COX-2 decrease significantly.The serum level of COX-2 can be used as one of the Hp eradication efficacy evaluation indicators.