血液灌流与血液滤过联用在重症有机磷农药中毒患者中的抢救效果分析

目的 评价血液灌流与血液滤过联用对于重症有机磷农药中毒(AOPP)患者的抢救效果.方法 选取2011年11月至2015年10月在本院抢救的重症AOPP患者72例,根据抢救方法不同分为对照组和观察组,每组各36例,其中对照组采取常规急救治疗,观察组在常规急救基础上采用血液灌流(HP)联合血液滤过(HF)治疗.比较两组患者的治疗效果及并发症情况.结果 观察组患者阿托品用量、清醒时间、ChE活性恢复正常时间、住院天数及术后并发症发生率均显著低于对照组(P＜0.05);观察组治愈率显著高于对照组(91.67％ vs.66.67％,P＜0.05).结论 血液灌流与血液滤过联用可有效提高重症AOPP患者的存活率,减少并发症的发生,是一种安全高效的AOPP治疗方式.

The effect of blood perfusion combined with blood filtration in the treatment of patients with severe acute organophosphorus pesticide poisoning

Objective To evaluate the effect of blood perfusion combined with blood filtration in the treatment of patients with severe acute organophosphorus pesticide poisoning (AOPP).Methods 72 patients with severe AOPP in our hospital from November 2011 to October 2015 were divided into control group and observation group according to the rescue method,36 cases in each group.Control group was treated with routine emergency treatment,while observation group was treated with blood perfusion combined with blood filtration on the basis of conventional first aid.The treatment effect and complications of two groups were compared.Results Atropine dosage,awake time,ChE activity recovery time,the length of stay and the incidence of postoperative complications of observation group were significantly lower than those of control group (P＜0.05); the cure rate of observation group was significantly higher than that of control group (91.67％ vs.66.67％,P＜0.05).Conclusion The combination of blood perfusion and blood filtration can effectively improve the survival rate of patients with severe AOPP,and reduce the incidence of complications,which is a safe and effective way to treat AOPP.