CA125、CA153、CA199、CEA联合检测对肺癌与肺结核的鉴别诊断价值

目的 研究分析在肺癌与肺结核鉴别诊断中使用CA125、CA153、CA199、CEA联合检测的诊断价值.方法 选取本院2014年1月至2015年2月收治的128例肺癌与肺结核患者,其中74例为恶性肿瘤组,54例为良性病变组,并且选取同期来本院体检者60例为对照组,使用CA125、CA153、CA199、CEA联合检测,观察各项指标的水平变化情况、敏感度、准确度与特异度.结果 在血清CA125、CA153、CA199、CEA检测中,良性病变组CA125、CA153、CA199、CEA水平稍微高于对照组,但两组比较差异无统计学意义(P＞ 0.05).恶性肿瘤组的血清CA125、CA153、CA199、CEA水平明显高于良性病变组与对照组,差异具有统计学意义(P＜0.05).CA125、CA153、CA199、CEA联合检测的灵敏度、特异性以及准确度明显优于各项单一检测值,差异具有统计学意义(P＜0.05).结论 在肺癌以及肺结核等呼吸系统肿瘤中,使用CA125、CA153、CA199、CEA联合检测可以有效的提高该类肿瘤的检测率,具有较高的临床应用价值.

Combined detection of CA125, CA153, CA199, and CEA in the differential diagnosis of lung cancer and pulmonary tuberculosis

Objective To study the diagnostic value of combined detection of CA125,CA153,CA199,and CEA in the differential diagnosis of lung cancer and pulmonary tuberculosis.Methods 128 cases of pulmonary tuberculosis or lung cancer in our hospital from January 2014 to February 2015 were selected,including 74 cases of malignant tumor,54 cases of benign lesion.60 persons undergoing medical examination in our hospital in the same period were selected as control group.Detected CA125,CA153,CA199,and CEA,observed the change in the levels of the indicators,sensitivity,accuracy and specificity.Results The levels of serum CA125,CA153,CA199,CEA of benign lesion group were slightly higher than those of control group,without statistically significant differences (P＞0.05).The levels of serum CA125,CA153,CA199,CEA of malignant tumor group were significantly higher than those of benign lesion group and control group,with statistically significant differences (P＜0.05).The sensitivity,accuracy and specificity of combined detection of CA125,CA153,CA199,and CEA were significantly better than those of each single detection indicator,with statistically significant differences (P＜0.05).Conclusion In patients with lung cancer,pulmonary tuberculosis,and other respiratory tumors,combined detection of CA125,CA 153,CA 199,CEA can improve the detection rate,with a high clinical value.