胎盘多肽注射液联合阿德福韦酯片对乙型肝炎肝硬化失代偿期患者肝及免疫功能的影响

目的 探讨胎盘多肽注射液联合阿德福韦酯片对乙型肝炎肝硬化失代偿期患者肝及免疫功能的影响.方法 选取2013年4月至2014年12月本院收治的乙型肝炎肝硬化失代偿期患者82例为研究对象,随机分为观察组和对照组,各41例.对照组口服阿德福韦酯片并进行保肝、休息和营养支持治疗,观察组在此基础上注射胎盘多肽注射液,均治疗3个月后比较两组肝及免疫功能,同时记录毒副作用发生率.结果 观察组治疗后ALT(48.88±2.21) U/L]、TBil(14.86±0.93)μmol/L]水平明显低于对照组(52.37±2.73) U/L、(17.21±1.05)μmol/L],观察组PT(12.11±0.98)s]较对照组(13.46±1.24)s]短(P＜0.05);观察组外周血淋巴细胞CD3+(69.83±3.02)％]、CD4+(42.96±3.65)％]、NK(22.87±1.94)％]活性显著高于对照组(P＜0.05);两组毒副反应发生率差异无统计学意义(26.8％vs.19.5％,P＞0.05).结论 胎盘多肽注射液联合阿德福韦酯片对乙型肝炎肝硬化失代偿期患者肝、免疫功能有明显改善作用,治疗安全性较好,值得临床推广.

Effect of adefovir dipivoxil combined with placenta polypeptide injection on liver function and immune function in patients with decompensated hepatitis B liver cirrhosis

Objective To explore the effect of adefovir dipivoxil combined with placenta polypeptide injection on liver function and immune function in patients with decompensated hepatitis B liver cirrhosis.Methods From April,2013 to December,2014,82 patients with chronic hepatitis B cirrhosis treated at our hospital were divided into an observation group and a control group,41 cases for each group.The control group were treated with adefovir dipivoxil tablets and took liver-protecting,rest,and nutritional support therapy;in addition,the observation group were given placenta polypeptide injection.After 3 months' treatment,the liver and immune functions were compared between these two groups.The incidence of toxic and side effects was recorded.Results The levels ofALT (48.88±2.21)U/L vs.(52.37±2.73) U/L] and TBil (14.86±0.93) μmol/L vs.(17.21±1.05) μmol/L] were significantly lower and the PT (12.1140.98) s vs.(13.46±1.24) s] was significantly shorter in the observation group than in the control group (P＜0.05).The activities of CD3+,CD4+ and NK were (69.83±3.02)％,(42.96±3.65)％ and (22.87±1.94)％ in the observation group,which were significantly higher than those in the control group (P＜0.05).There was no statistical difference in the incidence of side effects between these two groups (26.8％ vs.19.5％,P＜0.05).Conclusions The curative effect of adefovir dipivoxil combined with placenta polypeptide injection on liver function and immune function in patients with decompensated hepatitis B liver cirrhosis is significant and has a better treatment safety,so it is worth being clinically generalized.