阿托伐他汀钙治疗颈动脉粥样硬化的疗效观察

目的 探讨阿托伐他汀钙治疗颈动脉粥样硬化的效果.方法 收集本院2014年1月至2015年2月收治的80例颈动脉粥样硬化患者,将其随机分为对照组与实验组.对照组口服辛伐他汀治疗,实验组口服阿托伐他汀钙治疗,比较两组治疗前后斑块相关指标、IMT、血脂与相关分子指标.结果 实验组治疗后斑块直径、斑块厚度、斑块面积、硬斑比例、IMT、TG、TC、LDL-C、BNP、Hs-CRP与MCP-1水平显著低于对照组,软斑比例与HDL-C水平显著高于对照组,差异具有统计学意义(P＜0.01).结论 阿托伐他汀钙治疗颈动脉粥样硬化效果显著,具有借鉴性.

Atorvastatin calcium in treatment of carotid atherosclerosis

Objective To investigate the efficacy of atorvastatin calcium in the treatment of carotid atherosclerosis.Methods 80 patients with carotid atherosclerosis admitted into our hospital from January,2014 to February,2015 were collected and randomly divided into a control group and an experimental group.The control group orally took simvastatin and the experimental group atorvastatin calcium.The plaque-related indicators,IMT,blood lipid,and related molecular indexes were compared between these two groups before and after the treatment.Results After the treatment,the diameter,thickness,and area of the plaque were smaller,the hard plaque ratio and the levels of IMT,TG,TC,LDL-C,BNP,Hs-CRP,and MCP-1 were lower,and the soft plaque ratio and the level of HDL-C were higher in the experiment group than in the control group,with statistical differences (P＜0.01).Conclusions Atorvastatin calcium in the treatment of carotid atherosclerosis is effective,so it is of reference in clinical practice.