Effect of Acute Gastric Electrical Stimulation on the Systemic Release of Hormones and Plasma Glucose in Dogs |
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Authors: | J H Xing Y Lei H R Ancha R F Harty J D Chen |
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Institution: | (1) Veterans Research Foundation, Oklahoma City, Oklahoma, USA;(2) Division of Gastroenterology, Oklahoma University Health Science Center, Oklahoma City, Oklahoma, USA;(3) Division of Gastroenterology, University of Texas Medical Branch, 301 University Boulevard, Galveston, 77555–0632, Texas, USA |
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Abstract: | This study evaluated the effect of gastric electrical stimulation (GES) with various parameters on plasma concentrations of
satiety-related peptides and glucose. GES was performed in nine healthy dogs via electrodes implanted in the middle of the
lesser curvature. Four sessions were performed in each animal: control, stimulation with IGS (implantable gastric stimulation
for obesity, 0.3 m sec), modified IGS (2 msec), and long pulses (300 msec). Blood samples were collected at 15 and 0 min before
the meal and at 15, 30, and 60 min after the meal. GES was initiated 30 min before the first blood sample and maintained throughout
collection. Plasma ghrelin, leptin, insulin and glucose were measured. The total AUCs of plasma ghrelin and leptin were not
significantly affected by GES. The total AUC of plasma insulin was significantly lower with IGS and long pulse parameters
(P < 0.05). The total AUC for plasma glucose was significantly lower in sessions with long pulses and modified IGS parameters
(P < 0.05). We conclude that acute GES is able to change the release of some satiety-related peptides. Whether this is associated
with the changed eating behavior and weight loss in obese patients needs further investigation. |
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Keywords: | Gastric electrical stimulation Ghrelin LeptinI Insulin Glucose |
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