Different mechanisms are involved in the respiratory depression and analgesia induced by neurotensin in rats |
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Authors: | A Pazos M López J Flórez |
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Affiliation: | Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Santander, National Medical Center ‘M. de Valdecilla’, Santander, Spain |
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Abstract: | The tridecapeptide neurotensin (NT), injected intracerebroventricularly in rats, induced a naloxone-insensitive and dose-dependent analgesia (tail-flick test), the ED50 being 3.22 nmol/animal. Higher doses induced a dose-dependent respiratory depression, mostly accounted for by a reduction of frequency; the ED50 for this action was 144.6 nmol/animal. In contrast to analgesia, the respiratory depression was antagonized by naloxone, suggesting the possibility that NT and opioid systems might interact at the level of respiration-related nuclei. |
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Keywords: | Neurotensin Respiratory depression Analgesia Naloxone antagonism |
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