高血压患者动态动脉硬化指数与微量白蛋白尿关系的相关性分析

目的:动态动脉硬化指数(ambulatory arterial stiffness index,AASI)是一个反映动脉硬度的新指数。本文旨在探讨动脉动态硬化指数与微量白蛋白尿(MAU)的相关性。方法:本研究从2009年1月-2010年2月在心内科因高血压就诊患者中选取120例,其中MAU阳性患者32例为试验组,88例MAU阴性患者为对照组,均行动态血压监测、颈动脉IMT、心电图、尿微量白蛋白、血糖、血脂等检查。结果:MAU阳性组患者AASI、脉压水平显著高于MAU阴性组(P<0.05)。结果显示MAU、AASI有明显相关关系,呈正相关(r=0.432,P<0.05)。结论:本研究显示动态动脉硬化指数与MAU有明显相关关系。MAU越大,动态动脉硬化指数越增大;脉压越大,动态动脉硬化指数也越增大。

Correlation between Ambulatory Arterial Stiffness Index and Microalbuminuria in Hypertension Patients

Objective： Ambulatory arterial stiffness index（AASI）is a novel arterial stiffness measure, This article aims to explore the relationship between AASI and microalbuminuria. Methods： The enrolled were 120 patients with hyper tension who underwent 24h ambulatory blood pressure monitoring, microalbuminuria, blood glucose,plasma cholesterol examinations from Jan. 2009 to Feb. 2010. 120 patients were divided into two groups according to the MAUl level. 88 patients were normoalbuminuria group, 32 patients were MAU group. Results：Linear regression showed that AASI correlated positively with microalbuminuria in the whole cohort（r= 0. 432, P〈0. 05）. Conclusion：Our study suggested that AASI was an estimate of arterial stiffness measure through 24h ambulatory monitoring data, and correlated with mi croalbuminuria. AASI had some relationship with blood pressure circadian rhythm.