| VIP在慢性便秘大鼠结肠肌间神经丛中的表达和意义 |
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| 引用本文： | 杜丽娟,唐学贵,吴至久,李敏.VIP在慢性便秘大鼠结肠肌间神经丛中的表达和意义[J].医学理论与实践,2011,24(15):1755-1756. |
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| 作者姓名： | 杜丽娟 唐学贵 吴至久 李敏 |
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| 作者单位： | 川北医学院附属医院,四川省南充市,637000 |
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| 摘 要： | 目的:观察VIP在慢性便秘大鼠结肠肌间神经丛中的表达情况,探讨VIP在其发病中作用。方法:复方地芬诺酯建立慢性便秘大鼠模型,采用免疫组织化学SP法检测正常对照组和模型组的表达情况,应用彩色病理图像分析系统对阳性表达的平均光密度值(MD)进行半定量比较分析。结果:发现正常对照组和慢传输型便秘模型组大鼠的结肠肌间神经丛内均有VIP表达;检测两组中免疫组织化学VIP阳性表达平均吸收光密度值,发现模型组MD值高于正常对照组,两者比较差异具有统计学意义(P<0.05)。结论:血管活性肠肽的分布异常可能与慢性便秘的发病相关。
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| 关 键 词： | 慢性便秘 血管活性肠肽 结肠 肠神经系统 |
Expression and Significance of VIP in Colon Tissues of Chronic Constipation Model Rats |
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| DU Lijuan,TANG Xuegui,WU Zhijiu,et al..Expression and Significance of VIP in Colon Tissues of Chronic Constipation Model Rats[J].The Journal of Medical Theory and Practice,2011,24(15):1755-1756. |
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| Authors: | DU Lijuan TANG Xuegui WU Zhijiu |
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| Institution: | DU Lijuan,TANG Xuegui,WU Zhijiu,et al.Affiliated Hospital of North Sichuan Medical College,Nanchong City,Sichuan Province 637000 |
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| Abstract: | Objective:To observe the expression of VIP of neural cells in colon tissues in the chronic constipation model rats,and investigate the roles of VIP in the etiology of chronic constipation.Methods:The chronic constipation models were established by irrigating the rat's stomach with Diphenoxylate.To compare VIP expression by the immunohistochemistry staining in colon tissues.The staining results were analyzed Semiquantativeky by computerized color image analyzer using the following parameters:mean density(MD)... |
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| Keywords: | Chronic constipation Vasoactive intestinal peptide(VIP) Colon Enteric nervous system |
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