外源性SOD减轻大剂量照射对小鼠的损伤效应

报道５Ｇｙ６０Ｃｏγ射线照射后１、３、５、８ｄ对小鼠心、脑、肝组织中ＬＰＯ含量和ＳＯＤ活力的影响，以及小鼠受照射后，立即由其腹腔注射外源性ＳＯＤ，观察在上述４个时间点３种组织中ＬＰＯ含量改变情况。结果表明：小鼠受照后，其肝脏中ＬＰＯ含量最早发生变化，而心、脑ＬＰＯ含量在照后第８天才出现明显改变。同时上述组织中的ＳＯＤ活力，与对照组相比也明显下降（Ｐ＜０．０１）。注入ＳＯＤ后，照后不同时间测定ＬＰＯ含量、ＳＯＤ活力与对照组相比，分别降低和升高，说明ＳＯＤ酶具有明显的抗辐射作用。

The Decreasing Effect of Exogenous SOD on Damage of Mice Irradiated with 5Gy 60Co- Rays

This paper presents a report on the activity of Superoxide Dismutase (SOD) and the content of LPO measured in tissue of Liver,heart and brain of mice irradiated by60Co rays 5 Gy 1,3,5 and 8 days after irradiation respectively.After radiation exogenous SOD was immediatly i.p.injected into mice.The variation of LPO content in the above mentioned three kinds of tissuse has been observed.The result of the measurement shows that after radiation at a dose of 5 Gy60Co rays,the LPO content and SOD activity of mice organs varied with radiation time.The LPO content varied earliest in liver,while the variatio of LPO content in heart and cerebrum took place 8 days after radiation,meanwhile the activity of SOD in the tissues significantly decreased in comparason with that the control group (P<0.01) .After injection with SOD,the LPO content and SOD activity of the organs irradiated for different time significantly decreased and increased in comparason with that in the control group.This shows that the enzyme of SOD is of sijnificant antiradiation effect.