氯沙坦对高血压患者胰岛素抵抗的影响

目的 :观察氯沙坦对原发性高血压患者胰岛素抵抗 (IR)的影响。方法 :30例正常健康者和 35例原发性高血压患者分别进行口服葡萄糖耐量试验 (OGTT) ,测血糖 (GLU)、胰岛素 (INS)、C肽 (CP)等。原发性高血压组用氯沙坦治疗 8周后复查上述指标。结果 :高血压患者空腹血糖 (FG)、空腹胰岛素 (FINS)、餐后SG2 、INS2 均高于正常组 (P <0 .0 5 ) ,但胰岛素敏感性 (ISI)低于正常组 (P <0 .0 5 )。氯沙坦治疗 8周后胰岛素曲线下面积 (AUC]I)、C肽曲线下面积 (AUC]CP)均明显下降 (P <0 .0 5 ) ,ISI明显增高 (P <0 .0 5 ) ,CP/INS治疗前后无明显变化 (P >0 0 5 )。结论 :高血压患者存在胰岛素抵抗 ,氯沙坦在降压的同时可改善高血压患者的IR ,提高其ISI。

Influence of Losartan on Insulin Resistance in Patients with Hypertension

Objective:To study the influence of Losartan on insulin resistance(IR) in patients with primary hypertension. Methods: Oral glucose tolerant test (OGTT) was done in 30 normal individuals (normal control) and 35 cases of primary hypertension. The levels of blood glucose,insulin (INS) and C peptide (CP) were determined. 8 weeks after the treatment with Losartan in the hypertension group,the above indices were determined again. Results The levels of blood glucose and insulin before and after meals were significantly higher,while the insulin sensitivity (ISI) was lower in the hypertension group than those in the control group ( P <0.05). 8 weeks after the treatment,the area under curve of insulin (I) and C peptide (CP) remarkably decreased ( P <0.05),while ISI significantly increased ( P <0.05). CP/INS Showed no significant difference before and after the treatment ( P >0.05). Conclusion: Insulin resistance exists in patients with hypertension,which can be improved by Losartan treatment.